Publication detail

Synthesis of salicylamide-based pseudopeptides terminated with aldehydes or vinyl sulfone functional group as potential proteasome inhibitors

Year: 2019

Type of publication: ostatní - přednáška nebo poster

Page from-to: nestránkováno

Titles:

Language	Name	Abstract	Keywords
eng	Synthesis of salicylamide-based pseudopeptides terminated with aldehydes or vinyl sulfone functional group as potential proteasome inhibitors	Our research group developer novel O-benzyl salicylamide-based proteasome inhibitors built from L-leucine and L-phenylalanine.1 These compounds contain various functional groups such as aldehydes or weinreb amides or epoxyketones at the C-end of molecule. Our ongoing research investigated other functional groups with higher stability than aldehyde group. We also investigated influence of amino acid sequence in peptide chain on the inhibition activity. Synthesis of intermediates and targeted molecules was done in respect of high optical purity. Classical approaches known from peptide chemistry were applied and carefully optimized. Several new compounds with aldehyde or vinylsulfone group were prepared (Fig. 1) and their cytotoxicity as well as proteasome inhibition is under evaluation.	Proteasome Inhibition; Pseudopeptides; O-benzyl salicylamides

Search