Publication detail

FTIR Study of the Interactions Between Alginate and Chitosan Biopolymers During Dissolution Process

Authors: Matzick Kevin | Slezáková Barbora | Lochař Václav | Komersová Alena

Year: 2019

Type of publication: ostatní - článek ve sborníku

Name of source: 7th International Conference on Chemical Technology : book of abstracts

Publisher name: Česká společnost průmyslové chemie

Place: Praha

Page from-to: P54-P54

Titles:

Language	Name	Abstract	Keywords
eng	FTIR Study of the Interactions Between Alginate and Chitosan Biopolymers During Dissolution Process	Hydrophilic matrix tablets with tramadol hydrochlorid (TH), sodium alginate and chitosan were prepared by direct compression method. The release of TH from prepared drug formulations was studied by the dissolution test method according to the European Pharmacopoeia 9 th using paddle apparatus (Sotax AT 7 Smart, Allschwil, Switzerland). Dissolution tests were perfomed in various aqueous solutions of different pH values and ionic strength (redistilled water, acidic medium pH 1.2 simulating gastric fluid and phosphate buffer pH 6.8). IR spectra were measured on a Nicolet 6700 FTIR spectrometer. Spectra were scanned in the range of wavenumber from 4000 to 400 cm-1 at spectral resolution of 4 cm-1 and with the number of scans 64.	dissolution; tramadol; alginate; chitosane; interaction

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