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The effect of alcohol on ionizing and non-ionizing drug release from hydrophilic, lipophilic and dual matrix tablets
Authors: Lochař Václav | Komersová Alena | Matzick Kevin | Skalická Barbora | Bartoš Martin | Muzikova Jitka | Haddouchi Samir
Year: 2020
Type of publication: článek v odborném periodiku
Name of source: Saudi Pharmaceutical Journal
Publisher name: Elsevier Science BV
Place: Amsterdam
Page from-to: 187-195
Titles:
Language Name Abstract Keywords
cze Vliv alkoholu na ionizující a neionizující léčiva uvolňovaná z hydrofilních, lipofilních a duálních matric Cílem práce bylo studium vlivu přítomnosti alkoholu při uvolňování léčiv z hydrofilních, lipofilních i duálních matric. matrice; léčivo; alkohol; disoluce
eng The effect of alcohol on ionizing and non-ionizing drug release from hydrophilic, lipophilic and dual matrix tablets The aim of this work was to investigate and quantitatively evaluate the effect of presence of alcohol on in vitro release of ionizing and non-ionizing drug from hydrophilic, lipophilic and hydrophilic-lipophilic matrix tablets. The Food and Drug Administration (FDA) recommends in vitro dissolution testing of extended release formulations in ethanolic media up to 40% because of possible alcohol-induced dose dumping effect. This study is focused on comparison of the dissolution behavior of matrix tablets (based on hypromellose and/or glyceryl behenate as retarding agent) of the same composition containing different type of drug - ionizing tramadol hydrochloride (TH) and non-ionizing pentoxifylline (PTX). The dissolution tests were performed in acidic medium (pH 1.2) and in alcoholic medim (20%, 40% of ethanol) and the changes of tablets were observed also photographically. It was found that the alcohol resistence of the hydrophilic-lipophilic formulations with TH and the hydrophilic-lipophilic formulations with PTX containing a higher amount of hypromellose does not reflect the alcohol resistence of the formulations with pure hypromellose or glyceryl behenate. Both hydrophilic-lipophilic formulation with TH and more lipophilic formulation with PTX show significant alcohol dose dumping effect. (C) 2019 The Author(s). Published by Elsevier B.V. on behalf of King Saud University. Hypromellose; Glyceryl behenate; Alcohol; Tramadol hydrochloride; Pentoxifylline; Dissolution

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