University of Pardubice Faculty of Chemical Technology

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Metal nanoparticles-based electrochemical immunosensors for sensitive detection of protein biomarkers

Authors: Kastrati Gylxhane | Korecká Lucie | Bílková Zuzana

Year: 2021

Type of publication: ostatní - přednáška nebo poster

Page from-to: nestránkováno

Titles:

Language	Name	Abstract	Keywords
eng	Metal nanoparticles-based electrochemical immunosensors for sensitive detection of protein biomarkers	Currently, immunosensors have taken a lot of attention for their rapid responses, low-cost, simple, and most important integrable on point-of-care technology for detecting proteins [1-3]. Hence, an electrochemical immunosensor has been developed for simultaneous determination of selected protein biomarkers with clinical significance. For this immunoassay, the sandwich arrangement of immunocomplex formation has been preferred, which is composed of immunosorbent and bioconjugate. The immunosorbent consists of magnetic beads immobilized with primary antibodies, helped to concentrate protein, reduce purification steps, and nonspecific sorption. Whereas the bioconjugate include secondary antibodies, labelled with electroactive metal nanoparticles, and combined with mesoporous silica nanoparticles.	Quantum dots; Electrochemical immunosensor; antibodies; biomarker