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3D-Printed Coating of Extended-Release Matrix Tablets: Effective Tool for Prevention of Alcohol-Induced Dose Dumping Effect
Year: 2021
Type of publication: článek v odborném periodiku
Name of source: Pharmaceutics
Publisher name: MDPI
Place: BASEL
Page from-to: "2123-1"-"2123-27"
Titles:
Language Name Abstract Keywords
cze 3D-tištěný povlak matricových tablet s prodlouženým uvolňováním: Účinný nástroj pro prevenci alkoholem indukovaných ztrát léčiva Tablety používané pro prodloužené uvolňování běžně obsahují rozsáhlé množství léčiv. Z toho důvodu je třeba zabránit nekontrolovanému uvolˇbnování léčiva vedoucímu ke ztrátám. Tyto ztráty bývají často způsobeny přítomností alkoholu. HME; 3D tisk potahu tablet; tablety s prodlouženým uvolňováním; ztráty léčiva vlivem alkoholu; disoluční testy
eng 3D-Printed Coating of Extended-Release Matrix Tablets: Effective Tool for Prevention of Alcohol-Induced Dose Dumping Effect Tablets used for extended drug release commonly contain large amounts of drugs. The corresponding drug release mechanism thus has to be well-known and invariable under numerous conditions in order to prevent any uncontrolled drug release. Particularly important is the stability and invariability of the release mechanism in the presence of alcohol due to the possible occurrence of the dose dumping effect. The effect of 3D printing (3DP) coating on the drug release mechanism and the drug release rate was studied as a possible tool for the prevention of the alcohol-induced dose dumping effect. Three types of matrix tablets (hydrophilic, lipophilic, and hydrophilic-lipophilic) were prepared by the direct compression method and coated using 3DP. The commercial filament of polyvinyl alcohol (PVA) and the filament prepared from hypromellose by hot melt extrusion (HME) were used as coating materials. Both coating materials were characterized by SEM, DSC, Raman spectroscopy, and PXRD during particular stages of the processing/coating procedure. The dissolution behavior of the uncoated and coated tablets was studied in the strongly acidic (pH 1.2) and alcoholic (40% of ethanol) dissolution media. The dissolution tests in the alcoholic medium showed that the Affinisol coating was effective in preventing the dose dumping incidence. The dissolution tests in the acidic dissolution media showed that the Affinisol coating can also be useful for the delayed release of active substances. hot melt extrusion (HME); 3D printing and coating; dissolution testing; alcohol-induced dose dumping effect; Affinisol; polyvinyl alcohol

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