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A New Approach to the Dissolution Tests Management to Obtain Kinetic and Thermodynamic Data: Release of a Model Drug from Glyceryl Behenate Matrix Tablets
Authors: Skalická Barbora | Matzick Kevin | Komersová Alena | Lochař Václav | Bartoš Martin | Muzikova Jitka | Haddouchi Samir
Year: 2021
Type of publication: článek v odborném periodiku
Name of source: European Journal of Lipid Science and Technology
Publisher name: Wiley-VCH
Place: Weinheim
Page from-to: "2000235-1"-"2000235-8"
Titles:
Language Name Abstract Keywords
cze Nový přístup k managmentu disolučních testů a získání kinetických a termodynamických dat:: Uvolňování modelového léčiva z matricové tablety založené na glyceryl behenátu Studie je zaměřena na použití glyceryl behenátu jako lipofilního excipientu matricové tablety s prodlouženým uvolňováním. Cílem studie byl vývoj aktivační energie a změn termodynamických paramaetrů disolučního procesu. Compritol 888 ATO; glyceryl behenát; lipofilní matricové tablety; termodynamika
eng A New Approach to the Dissolution Tests Management to Obtain Kinetic and Thermodynamic Data: Release of a Model Drug from Glyceryl Behenate Matrix Tablets This study is focused on the use of glyceryl behenate as a lipophilic excipient of matrix tablets providing controlled drug release. The aim of this study is to evaluate activation energy (EA) and changes of the thermodynamic parameters (Delta H, Delta S, Delta G) of a dissolution process. These values, which have not yet been published, can lead to better understanding of a drug release mechanism and can extend the use options of glyceryl behenate in the pharmaceutical industry. Values of Delta H, Delta S, Delta G and E-A, providing an overall thermodynamic view on the studied matrix tablets, are evaluated based on the temperature-dependences of the release rate constant of a model drug (temperature range 25 - 45 degrees C). The studied lipophilic matrix tablets contain 10% to 50% of glyceryl behenate. Dissolution testing is carried out in an aqueous solution of HCl with addition of NaCl (pH1.2). Positive values of Delta H in the range of 3.83 to 56.13 kJ mol(-1) and positive values of Delta G indicate that the dissolution of the studied glyceryl behenate matrix tablets is an endothermic process which does not proceed spontaneously (in a temperature range of 25 - 45 degrees C). The negative slope of the linear curves of enthalpy-entropy compensation confirms the entropy-driven dissolution. Compritol 888  ATO; glyceryl behenate; lipophilic matrix tablets; thermodynamics

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