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Determination of Ranitidine Based on Derivatization Reaction at Glassy Carbon Paste Electrode Modified with SDBS

Authors: Shabani Egzontina | Veseli Vulnet | Bílková Zuzana | Berisha Liridon

Year: 2022

Type of publication: ostatní - přednáška nebo poster

Page from-to: nestránkováno

Titles:

Language	Name	Abstract	Keywords
eng	Determination of Ranitidine Based on Derivatization Reaction at Glassy Carbon Paste Electrode Modified with SDBS	Ranitidine is a potent H2-receptor antagonist commonly used in treating duodenal and gastric ulceration, gastroesophageal reflux disease, Zollinger-Ellison syndrome, and other diseases involving high gastric acid secretion, and due to the importance of ranitidine, several analytical methods have been reported for its determination. A new electroanalytical method has been developed for the determination of ranitidine in pharmaceutical products. This method is based on the reduction of 2-methylfuran cation-product of the reaction of ranitidine with sodium nitrite in 0.05 M Britton-Robinson buffer pH 2, whose sensitivity is based on the use of sodium dodecylbenzenesulfonate (SDBS) as a surface modifier at glassy carbon paste electrodes using differential pulse voltammetry. At lower concentrations, sodium dodecylbenzenesulfonate formed a negatively charged monolayer on the glassy carbon electrodes surface because of hydrophobic interactions of the hydrophobic chain of the surfactant and silicon oil of GCPE. The optimum voltammetric response was obtained when dropping ten μL of SDBS 2 mM on GCPE’s surface. The developed method is characterized by a wide linear range from 0.3 to 254 μM, with a detection limit of 18.6 nM. The built platform is used to determine ranitidine in pharmaceutical formulations with acceptable recovery, thus demonstrating the practical application of this method in fundamental analysis.