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Voltammetric Determination of Ranitidine in Pharmacaeutical Products Using SDBS As Surface Modifier Of Glassy Carbon Paste Electrode

Authors: Shabani Egzontina | Veseli Vulnet | Bílková Zuzana | Berisha Liridon

Year: 2022

Type of publication: ostatní - přednáška nebo poster

Page from-to: nestránkováno

Titles:

Language	Name	Abstract	Keywords
eng	Voltammetric Determination of Ranitidine in Pharmacaeutical Products Using SDBS As Surface Modifier Of Glassy Carbon Paste Electrode	Ranitidine, known as one of the histamine H2 receptor antagonists, is widely used to treat gastric ulcers, duodenal ulcers, gastroesophageal reflux disease, and gastric acidity, accompanied by various effects Zollinger-Ellison syndrome and other diseases involving high gastric acid secretion [1]. Due to the importance of ranitidine, several analytical methods have been reported for its determination. A new electroanalytical method based on the modification of glassy carbon paste electrode (GCPE) with sodium dodecylbenzenesulfonate (SDBS) has been developed to determine ranitidine in pharmaceutical products. Quantitative determination of ranitidine is based on reducing the 2-methylfuran cation - a product of the ranitidine-nitrite reaction [2]. SDBS formed a negatively charged monolayer at lower concentrations on the glassy carbon electrode surface because of hydrophobic interactions of the hydrophobic chain of the surfactant and the silicon oil of GCPE [3]. Furthermore, the modification of GCPE with this anionic surfactant effectively increases the sensitivity to the reaction product of ranitidine with sodium nitrite at 0.05 M Britton-Robinson buffer at pH 2. The optimum voltammetric response was obtained when dropping 10 μL of SDBS 2 mM on GCPE’s surface. The developed method is characterized by a wide linear range and a low detection limit of 18.6 nM. The built platform is used to determine ranitidine in pharmaceutical products with acceptable recovery, thus demonstrating the practical application of this method in fundamental analysis.