University of Pardubice Faculty of Chemical Technology

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Synthesis of an effective MRSA inhibitor based on trifluoromethyl diamide caffold.

Authors: Pilařová Eliška | Pauk Karel | Magar Pratibha | Imramovský Aleš | Pindjaková Dominika | Čížek Alois | Jampílek Josef

Year: 2022

Type of publication: ostatní - přednáška nebo poster

Page from-to: nestránkováno

Titles:

Language	Name	Abstract	Keywords
eng	Synthesis of an effective MRSA inhibitor based on trifluoromethyl diamide caffold.	In this research, compounds containing 4-(trifluoromethyl) aniline were prepared. These substances were highly active against 4 strains, namely Staphylococcus aureus, methicillin-resistant S. aureus, Bacillus cereus and Clostridium perfringens. Based on this, we decided to expand this series of substances with other amino acids. Monopeptide acid was used as a starting material, which was coupled with 4-trifluoromethyl aniline, followed by debenzylation with hydrogen. Both benzylated and debenzylated substances were tested for antibacterial activities.	MRSA inhibitor; trifluoromethyl diamide;