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Matrix Tablets Based on Chitosan-Carrageenan Polyelectrolyte Complex: Unique Matrices for Drug Targeting in the Intestine
Authors: Komersová Alena | Svoboda Roman | Skalická Barbora | Bartoš Martin | Snejdrova Eva | Muzikova Jitka | Matzick Kevin
Year: 2022
Type of publication: článek v odborném periodiku
Name of source: Pharmaceuticals
Publisher name: MDPI
Place: BASEL
Page from-to: "980-1"-"980-25"
Titles:
Language Name Abstract Keywords
cze Matricové tablety založené na Chitosan-Carrageenan polyelektrolytových komplexech: Unikátní matrice pro cílení léčiv ve střevech Studie se zaměřila na detailní charakterizaci chitosan-carrageenan matricové tablety a jejich potenciál v cíleném uvolňování léčiva ve střevech. Byla provedená systematická studie partikulárních stádií disolučního procesu z pohledu různých fyziko-chemických vlastností. polyelektrolytový komplex; carrageenan; chitosan; cílení léčiva
eng Matrix Tablets Based on Chitosan-Carrageenan Polyelectrolyte Complex: Unique Matrices for Drug Targeting in the Intestine The present study focused on the more detailed characterization of chitosan-carrageenan-based matrix tablets with respect to their potential utilization for drug targeting in the intestine. The study systematically dealt with the particular stages of the dissolution process, as well as with different views of the physico-chemical processes involved in these stages. The initial swelling of the tablets in the acidic medium based on the combined microscopy-calorimetry point of view, the pH-induced differences in the erosion and swelling of the tested tablets, and the morphological characterization of the tablets are discussed. The dissolution kinetics correlated with the rheological properties and mucoadhesive behavior of the tablets are also reported, and, correspondingly, the formulations with suitable properties were identified. It was confirmed that the formation of the chitosan-carrageenan polyelectrolyte complex may be an elegant and beneficial alternative solution for the drug targeting to the intestine by the matrix tablet. polyelectrolyte complex; carrageenan; chitosan; drug targeting

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