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USING OF 3D-PRINTED COATING OF MATRIX TABLETS FOR PREVENTION OF ALCOHOL-INDUCED DOSE DUMPING EFFECT

Authors: Skalická Barbora | Matzick Kevin | Macháčková Jana | Komersová Alena

Year: 2022

Type of publication: ostatní - přednáška nebo poster

Page from-to: nestránkováno

Titles:

Language	Name	Abstract	Keywords
eng	USING OF 3D-PRINTED COATING OF MATRIX TABLETS FOR PREVENTION OF ALCOHOL-INDUCED DOSE DUMPING EFFECT	Presented in vitro study is primarily focused on release of the model drug tramadol hydrochloride from hydrophilic, lipophilic and dual matrix tablet in the acidic medium containing 40% alcohol. The evaluation of changes of the dissolution profiles due to the presence of alcohol was used as a suitable method for testing of the alcohol resistence of the uncoated and coated matrix tablets. As a coating material the commercial filament of polyvinyl alcohol (PVA) and the filament prepared from hypromellose by hot melt extrusion (HME) were used.	matrix tablets; dose dumping; 3D-printed coatings