University of Pardubice Faculty of Chemical Technology

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Synthesis of new potential drugs against Alzheimer's disease, their characterization and dissolution behaviour

Authors: Nevyhoštěná Marie | Komersová Alena | Macháčková Jana | Pejchal Vladimír | Štěpánková Šárka

Year: 2023

Type of publication: ostatní - přednáška nebo poster

Page from-to: nestránkováno

Titles:

Language	Name	Abstract	Keywords
eng	Synthesis of new potential drugs against Alzheimer's disease, their characterization and dissolution behaviour	A new report from the WHO shows that one billion people are influenced by neurological disorders worldwide. Neurological disorders affect people in all countries, no matter of age, sex, education or income. Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive dysfunction and dementia. Current estimates suggest that around 50 million people are affected by this disease. Unfortunately, drugs for AD and its progression have not yet been discovered. There are several approaches in the symptomatic treatment of AD. One of them is the use of the cholinesterase inhibitors (acetylcholinesterase and butyrylcholinesterase), which have a number of side effects. Therefore, a development of new and less toxic substances is of critical importance. A family of new compounds as potential AD drugs were prepared by six-step synthesis. A biological activity assay was performed, and in vitro behaviour of selected compounds was studied. Some substances displayed remarkable biological activity and became a subject of interest for further extensive testing.	Alzheimer's disease; dementia; cholinesterase inhibitors