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Ultrathin TiO2 ALD Coatings Enhance Properties of Biomaterials Used in Medicine

Authors: Báčová Jana | Baishya Kaushik | Čapek Jan | Zazpe Raul | Sopha Hanna Ingrid | Sepulveda Sepulveda Lina Marcela | Roušar Tomáš | Macák Jan

Year: 2024

Type of publication: ostatní - přednáška nebo poster

Page from-to: nestránkováno

Titles:

Language	Name	Abstract	Keywords
eng	Ultrathin TiO2 ALD Coatings Enhance Properties of Biomaterials Used in Medicine	TiO2 surfaces are in general recognized as excellent biocompatible materials owing to their resistance to body fluid effects, low ion release, high stability, antibacterial properties, and wetting ability. Various TiO2 nanostructured surfaces show great properties enhancing cell interactions. Anodic TiO2 nanotube (TNT) layers have emerged as extremely suitable and effective substrates for cell growth and proliferation. A pioneering study demonstrated that TNTs with a diameter of 15 nm are the most suitable surface for the growth of cells [1]. Several papers also showed that anodization is a great tool for surface modification of various materials used in biomedical applications, especially TiAlV. Recently, we demonstrated that ultrathin coatings by metal oxides (e.g. TiO2) using Atomic Layer Deposition (ALD) on TNT layers enhance cell adhesion, growth, and proliferation [2]. These properties make them excellent as the uppermost surfaces for bone and dental implants. The presentation deals with the comparison of the biological effect of ultrathin TiO2 ALD coatings achieved by various numbers of TiO2 ALD cycles on planar and nanotubular surfaces. For that Ti sheets and anodized TNT layers with a distinct inner diameter of 12 nm and 15 nm, were used as substrates, as they appear to be the most suitable for cell growth in general. We evaluated the cell adhesion, proliferation, and density of fibroblast, osteoblast, and neuroblast cells on these substrates [2,3]. Moreover, the single-cell adhesion of the cells to the TNT layers modified using ALD method was studied by the bio-Atomic Force Microscopy (bio-AFM) technique [3]. Finally, the biological effect of black form of TiO2 nanotubes in comparison to their classical counterparts was investigated for the first time. The black TiO2 nanotubes with TiO2 ALD coating can be considered as a potential candidate in various applications due to the disappearance of mild toxic effects of white and black TiO2 nanotubes due to	TiO2; nanotubes; osteoblasts; atomic layer deposition