Login for students

Login for employees

Publication detail

Biopolymer Hydroxypropyl Methylcellulose-Based Filaments Prepared by Hot-Melt Extrusion Suitable for Fused Deposition Modeling 3D Printing of Personalized Capsules
Year: 2025
Type of publication: článek v odborném periodiku
Name of source: 3D Printing and Additive Manufacturing
Publisher name: Mary Ann Liebert
Place: New York
Page from-to: 553-564
Titles:
Language Name Abstract Keywords
cze Biopolymerová vlákna na bázi hydroxypropylmethylcelulózy připravená vytlačováním za horka a vhodná pro modelování personalizovaných kapslí 3D tiskem Materiály na bázi hydroxypropylmethylcelulózy smíchané s různými biopolymery (BioP; 5 % hmotn. chitosanu, alginát sodný, jablečný pektin nebo citrusový pektin) byly zpracovány vytlačováním za tepla a 3D tiskem za účelem výroby kapslí určených pro řízené uvolňování léčiva. Mikroskopické analýzy potvrdily významný vliv BioP na teploty zpracování a kvalitu 3D tisku. Chemické složení kapslí mělo významnější vliv na profily rozpouštění v kyselém a neutrálním médiu, které jsou robustní funkcí mezimolekulárních vazeb a bobtnacích charakteristik konkrétního BioP (jak naznačují kombinované výsledky Ramanovy spektroskopie, diferenciální skenovací kalorimetrie a termogravimetrie). Biopolymerová vlákna; hydroxypropylmethylcelulózy; hot-melt extruze; 3D tisk; kapsle
eng Biopolymer Hydroxypropyl Methylcellulose-Based Filaments Prepared by Hot-Melt Extrusion Suitable for Fused Deposition Modeling 3D Printing of Personalized Capsules Materials based on the hydroxypropyl methylcellulose mixed with different biopolymers (BioP; 5 w% of chitosan, sodium alginate, apple pectin, or citrus pectin) were processed by hot-melt extrusion and 3D printing to produce capsules intended for controlled drug release. Microscopic analyses confirmed significant impact of BioP on the processing temperatures and quality of the 3D printing. The capsules' chemical composition had a more significant impact on the dissolution profiles in acidic and neutral media, which are a robust function of the intermolecular bonds and swelling characteristics of the particular BioP (as indicated by the combined results of Raman spectroscopy, differential scanning calorimetry [DSC], and thermogravimetry). The capsules of all tested compositions retained the model drug for 120 min in pH 1.2, i.e., fulfilled the condition of targeting the small intestine. The presence of the particular BioP was found to be particularly beneficial in the development of personalized capsules for oral administration. The addition of both pectins led to a relatively fast pH-independent release of the model drug and has the potential applications in the targeting of the duodenum or jejunum. The capsules containing alginate and chitosan exhibited later initial release in pH 1.2, guaranteeing an unaltered passage through the stomach environment. 3D printing; fused deposition modeling; hot-melt extrusion; capsules; biopolymers

Departments

Other Parts

Map

en.mapy.cz

Services

Popular Links

© 2023 University of Pardubice, Studentská 95, 532 10 Pardubice 2
Phone: +420 466 036 111, 466 036 112, 466 036 113
Webmaster, RSS
Data box ID: f5vj9hu
Accessibility Statement
CC BY-NC-ND 4.0Creative CommonsAttributionNonCommercialNoDerivatives