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Ultrathin ALDMetal Oxide Coatings on Ti-based Surfaces: Biocompatibility and Cytotoxicity Assessment

Authors: Báčová Jana | Baishya Kaushik | Čapek Jan | Roušar Tomáš | Macák Jan

Year: 2025

Type of publication: ostatní - přednáška nebo poster

Page from-to: nestránkováno

Titles:

Language	Name	Abstract	Keywords
eng	Ultrathin ALDMetal Oxide Coatings on Ti-based Surfaces: Biocompatibility and Cytotoxicity Assessment	TiO2 materials are recognized as excellent biocompatible materials, owing to their low cytotoxicity, high stability, antibacterial properties, and wetting ability. Numerous papers also showed that anodization is a viable tool for nanostructuring of various biomedical alloys, including modifications of frequently used TiAlV [1-4]. To further enhance their surface chemistry and cell interactions, ultrathin TiO₂ coatings realized by Atomic Layer Deposition (ALD) can be added to the surface [2-4]. In fact, a surface modification via ALD of metal oxides such as ZrO₂ and V₂O₅ recently emerged as a very promising strategy for functionalization of various surfaces. ZrO₂ is known for its stability and antibacterial effects, while vanadium oxides show a dose-dependent effect on cells, promoting growth at low levels but possibly being cytotoxic at higher concentrations. In this work, we demonstrate that ultrathin coatings by metal oxides (e.g., TiO2, ZrO₂, and V₂O₅) using ALD on Ti and TiAlV sheets or nanotubular surfaces enhance the cell adhesion, growth, and proliferation. These properties make them excellent as the uppermost surfaces for bone and dental implants [2-4]. The growth of osteoblast cells on surfaces of amorphous/crystalline TNT layers coated with ultrathin ALD ZrO2 and V2O5 was evaluated for the first time. The coated surfaces were estimated in terms of the effect of tube diameter, crystallinity, roughness, wettability, and surface chemistry on cell growth and elongation. It was found that crystalline 5c ZrO2 TNT with a diameter of 15 nm exhibited the most favorable effect on the cell growth and cytoskeleton development after 48 h. The expected cytotoxic effect of 5c V2O5 ALD on TNT layers with diameters of 30 and 100 nm on cells was confirmed. Our findings suggest that ultrathin ZrO2 ALD coatings hold significant promise for enhancing the biocompatibility of various surfaces, demonstrating strong potential for use in biomedical applications [5]. Reference	Atomic layer deposition; cells; osteoblasts; ZrO2; V2O5; proliferation