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TiO2, ZrO2, and V2O5 ALD Coatings on Titanium Biomaterials: Effects on Osteoblast Growth

Authors: Báčová Jana | Baishya Kaushik | Čapek Jan | Roušar Tomáš | Macák Jan

Year: 2025

Type of publication: ostatní - přednáška nebo poster

Page from-to: nestránkováno

Titles:

Language	Name	Abstract	Keywords
eng	TiO2, ZrO2, and V2O5 ALD Coatings on Titanium Biomaterials: Effects on Osteoblast Growth	TiO2 surfaces are recognized as excellent biocompatible materials, owing to their low cytotoxicity, high stability, antibacterial properties, and wetting ability. Numerous papers also showed that anodization is a viable tool for nanostructuring of various biomedical alloys, including modifications of frequently used TiAlV [1-4]. To further enhance their surface chemistry and cell interactions, atomic layer deposition (ALD) of ultrathin TiO₂ coatings is used [2-4]. Surface modification via ALD of metal oxides such as ZrO₂ and V₂O₅ can emerge as a promising strategy. ZrO₂ is known for its stability and antibacterial effects, while vanadium oxides show a dose-dependent effect on cells, promoting growth at low levels but possibly being cytotoxic at higher concentrations. In this presentation, we demonstrate that ultrathin coatings by metal oxides (e.g., TiO2, ZrO₂, and V₂O₅) using ALD on Ti and TiAlV sheets or nanotubular surfaces enhance cell adhesion, growth, and proliferation. These properties make them excellent as the uppermost surfaces for bone and dental implants [2-4]. The growth of osteoblast cells on surfaces of amorphous/crystalline TNT layers coated with ultrathin ALD ZrO2 and V2O5 was evaluated for the first time. The coated surfaces were estimated in terms of the effect of tube diameter, crystallinity, roughness, wettability, and surface chemistry on cell growth and elongation. It was found that crystalline 5c ZrO2 TNT with a diameter of 15 nm exhibited the most favorable effect on the cell growth and cytoskeleton development after 48 h. The expected cytotoxic effect of 5c V2O5 ALD on TNT layers with diameters of 30 and 100 nm on cells was confirmed. Our findings suggest that ultrathin ZrO2 ALD coatings hold significant promise for enhancing the biocompatibility of various surfaces, demonstrating strong potential for use in biomedical applications [5]. Moreover, the single-cell adhesion of the human gingival fibroblasts to the TNT layers modified usi	Osteoblasts; atomic layer depositon; ZrO2; V2O5, nanotubes; cells; proliferation