Univerzita Pardubice Fakulta chemicko- technologická

Univerzita Pardubice

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Publikace detail

Lipidomic characterization of kidney cancer tissues using HILIC-HPLC/ESI-MS

Autoři: Cífková Eva | Holčapek Michal | Lísa Miroslav | Vrána David | Melichar Bohuslav | Študent Vladimír

Rok: 2014

Druh publikace: ostatní do riv

Strana od-do: nestránkováno

Tituly:

Jazyk	Název	Abstrakt	Klíčová slova
cze	Lipidomic characterization of kidney cancer tissues using HILIC-HPLC/ESI-MS	Kidney cancer is one of the most common tumors both for men and women. Renal cell carcinoma (RCC) represents more than 90% of kidney cancer cases. Similarly to tumors of other primary locations, early detection of RCC and subsequent therapy increases the chance of cure. Lipid metabolism plays an important role in the oxidative stress and is associated with kidney cancer risk factors. The principal function of kidney is the filtration of blood and the excretion of excessive compounds and metabolites from body through urine. The HPLC/MS characterization of lipidomic differences between kidney cancer tissues and surrounding normal tissues is the first step, which is then followed by the search for these lipids with different expression in body fluids of kidney cancer patients compared to healthy vol
eng	Lipidomic characterization of kidney cancer tissues using HILIC-HPLC/ESI-MS	Kidney cancer is one of the most common tumors both for men and women. Renal cell carcinoma (RCC) represents more than 90% of kidney cancer cases. Similarly to tumors of other primary locations, early detection of RCC and subsequent therapy increases the chance of cure. Lipid metabolism plays an important role in the oxidative stress and is associated with kidney cancer risk factors. The principal function of kidney is the filtration of blood and the excretion of excessive compounds and metabolites from body through urine. The HPLC/MS characterization of lipidomic differences between kidney cancer tissues and surrounding normal tissues is the first step, which is then followed by the search for these lipids with different expression in body fluids of kidney cancer patients compared to healthy volunteers.	kidney cancer, lipids, HPLC, MS