Publikace detail

Study of antitumor effect of selected vanadium and molybdenum organometallic complexes in human leukemic T-cells

Autoři: Šebestová Lucie | Havelek Radim | Řezáčová Martina | Honzíček Jan | Kročová Zuzana

Rok: 2015

Druh publikace: článek v odborném periodiku

Název zdroje: Chemico-biological Interactions

Strana od-do: 61-70

Tituly:

Jazyk	Název	Abstrakt	Klíčová slova
cze	Studium vybraných organokovových sloučenin vanadu a molybdenu na leukemických buňkách	Tato práce popisuje cytotoxickou aktivity vybraných neplatinových sloučenin vůči leukemickým buňkám.	Organokovové sloučeniny; Apoptoza; MOLT-4; Jurkat; p53
eng	Study of antitumor effect of selected vanadium and molybdenum organometallic complexes in human leukemic T-cells	This work describes cytotoxic effect of non-platinum metal-based compounds on the human T-leukemic cells with different p53 status (p53 wild-type MOLT-4 and p53-deficient Jurkat cells). The cytotoxic and apoptosis-inducing effect of the vanadium complex [(η5-C5H5)2V(5-NH2-phen)]OTf (V1) and molybdenum complex [(η3-C3H5)Mo(CO)2(phen)Cl] (Mo1) were studied using flow cytometry, spectrophotometry and Western blotting. We found that the cytotoxic effect of both tested complexes after 24 h is higher against the both examined cell lines than that of cis-platin (cis-DDP). At later investigated time intervals of 48 and 72 h, the cytotoxic effect of the cis-DDP increased but the values of the cytotoxicity of the tested V1 and Mo1 complexes remained unchanged, with the cytotoxicity of V1 comparable to that of cis-DDP.	Organometallic compounds; Apoptosis; MOLT-4; Jurkat; p53

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