Publikace detail

Henry reaction catalyzed by new series of 5-tert-butyl-2-(pyridine-2-yl)imidazolidine-4-one Cu-complexes

Autoři: Horáková Eva | Drabina Pavel | Sedlák Miloš

Rok: 2015

Druh publikace: ostatní - přednáška nebo poster

Strana od-do: nestránkováno

Tituly:

Jazyk	Název	Abstrakt	Klíčová slova
eng	Henry reaction catalyzed by new series of 5-tert-butyl-2-(pyridine-2-yl)imidazolidine-4-one Cu-complexes	The aim of this work was preparation of 5-tert-butyl-2-(pyridine-2-yl)imidazolidine-4-one derivatives and their corresponding Cu(II) complexes. These compounds were studied as enantioselective catalysts for the asymmetric Henry reaction of various aldehydes with nitromethane. It was found the 5-tert-butyl derivatives are effective catalysts for this reaction, with enantiomeric excesses being as high as 97%. The enantioselectivities of individual derivatives are different and depend on the alkyl substituents attached to stereogenic centres and the configuration of imidazolidine-4-one cycle. The enantiocatalytic activity of most efficient derivative is comparable with the best so far known enantioselective catalysts of the Henry reaction.

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