Publikace detail

Využití HPLC v monitorování méně známých rizikových faktorů aterosklerózy

Autoři: Žáková Pavla | Kanďár Roman

Rok: 2006

Druh publikace: článek v odborném periodiku

Název zdroje: CHEMagazín

Název nakladatele: Ing. Miloslav Rotrekl - CHEMagazín

Místo vydání: Pardubice

Strana od-do: 8-9

Tituly:

Jazyk	Název	Abstrakt	Klíčová slova
cze	Využití HPLC v monitorování méně známých rizikových faktorů aterosklerózy	Several clinical studies have indicated that high plasma concentration of the sulphur aminoacid homocysteine is an independent risk factor for origin and progress of atherosclerosis. Increased levels of total plasma homocysteine can be treated with vitamins B6, B12 and folic acid. The most frequent methods for determination of total plasma homocysteine are immunochemical and HPLC methods. We have chosen an ion-paired reversed-phase HPLC method with coulometric electrochemical detection, without time-consuming derivatization. Oxidation of LDL is important event in etherosclerosis. Reduced form of coenzyme Q10 protects LDL from oxidative damage. We have measured reduced and oxidized forms of coenzyme Q10 using HPLC with coulometric electrochemical detection too.	ateroskleróza, homocystein, koenzym Q10, HPLC, coulometrická elektrochemická detekce
eng	Utilization of HPLC for monitoring of less-known risk factors of atherosclerosis	Several clinical studies have indicated that high plasma concentration of the sulphur aminoacid homocysteine is an independent risk factor for origin and progress of atherosclerosis. Increased levels of total plasma homocysteine can be treated with vitamins B6, B12 and folic acid. The most frequent methods for determination of total plasma homocysteine are immunochemical and HPLC methods. We have chosen an ion-paired reversed-phase HPLC method with coulometric electrochemical detection, without time-consuming derivatization. Oxidation of LDL is important event in etherosclerosis. Reduced form of coenzyme Q10 protects LDL from oxidative damage. We have measured reduced and oxidized forms of coenzyme Q10 using HPLC with coulometric electrochemical detection too.	atherosclerosis, homocysteine, coenzyme Q10, HPLC, coulometric electrochemical detection

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