Publikace detail

Oxidative stress and metabolic syndrome in obese patients

Autoři: Mužáková Vladimíra | Skalický Jiří | Kanďár Roman

Rok: 2006

Druh publikace: článek ve sborníku

Název zdroje: The FEBS Journal Supplement

Název nakladatele: Blackwell Publishing Ltd

Místo vydání: Oxford

Strana od-do: 201

Tituly:

Jazyk	Název	Abstrakt	Klíčová slova
cze	Oxidační stres a metabolický syndrom u obesních pacientů	Oxidační stres a metabolický syndrom u obesních pacientů	Oxidační stres; metabolický syndrom; obesní;
eng	Oxidative stress and metabolic syndrome in obese patients	The aim of this study was to evaluate the effect of oxidative stress in obese people with metabolic syndrome (MS). Free radical plasma levels and total antioxidant capacity were determined in obese people fulfilling at least 3 criteria of MS (MS, 15 patients), obese ones without MS (OB, 18 patients), and in 48 healthy controls (C). Free radical concentration was determined by direct method based on chlorophyllin acceptance of electrons, total antioxidant capacity using the kit TAS (Randox, UK). Plasma levels of glucose, triglycerides, HDL-ch, LDL-ch, fibrinogen, uric acid and BMI, waistline and blood pressure were followed. The highest level of free radicals was found in patients with metabolic syndrome. MS: 8.68 +- 3.70 mmol/l vs OB: 6.34 +- 1.80 mmol/l (p0.05) vs C: 4.71 +- 0.77 mmol/l (p0.01). Total antioxidant capacity was low in all groups. MS: 0.91 +- 0.12 mmol/l vs OB: 0.73 +- 0.10 mmol/l (p0.05) vs C: 0.81 +- 0.09 mmol/l (p0.05). In MS group significantly (p0.05) higher levels of glucose, triglycerides and uric acid and significantly (p0.001) lower level of HDL-ch were found. Our results confirm high significance of obesity as a risk factor leading to metabolic syndrome and cardiovascular disease, respectively. High levels of free radicals together with low total antioxidant capacity detected in case of patients with metabolic syndrome indicate elevation of the oxidative stress, which potentiates risk of atherogenesis.	Oxidative stress; metabolic syndrome; obese patients

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