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Oxidative stress and a-tocopherol level in patients with coronary artery disease

Rok: 2006

Druh publikace: ostatní - přednáška nebo poster

Název zdroje: Molecular and physiological effects of bioactive food compounds ? COST 926/927 Conference

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Jazyk	Název	Abstrakt	Klíčová slova
cze	Oxidační stres a hladina a-tokoferolu u nemocných s kardiovaskulárním onemocněním	Oxidační stres a hladina a-tokoferolu u nemocných s kardiovaskulárním onemocněním	Oxidační stres; a-tokoferol; kardiovaskulární onemocnění
eng	Oxidative stress and a-tocopherol level in patients with coronary artery disease	Growing amount of scientific evidence indicate that disbalance of redox equilibrium, enhanced by the increased insufficiency of antioxidant defense system, plays a role in development of atherosclerosis, which suggests that antioxidants may have a protective effect in prevention of disease development. An important antioxidant dietary component is -tocopherol, major chain-breaking antioxidant in body tissues. The aim of this study was to determine the level of oxidative stress and antioxidative status, including plasma concentration of -tocopherol, in patients with advanced coronary artery disease. Oxidative stress parameters were determined in group of patients with serious coronary artery disease (at least 50% stenosis of the left main coronary artery or 70% stenosis of other coronary artery according to coronarographic examination; S, n=40) and control group of examined patients with normal coronary arteries (normal coronarographic status; C, n=38). Free radical concentration was determined by direct method based on chlorophyllin acceptance of electrons, total antioxidant capacity by the kit TAS (Randox, UK), -tocopherol plasma concentration by HPLC. Plasma levels of malondialdehyde, allantoin, 1antiproteinase, glucose, total cholesterol, triglycerides, HDL-ch, LDL-ch, fibrinogen and glutathione in the whole blood were followed. In patients with coronary stenosis (S) higher level of free radicals (FR) coincided with lower level of lipid standardised -tocopherol (AT). FR: S: 5.11  0.58 mmol/l vs C: 4.60  0.79 mmol/l (p0.01); AT: S: 2.78  0.45 mol/l vs C: 3.00  0.39 (p0.05). Total antioxidant capacity was low in both groups; S: 0.81  0.15 mmol/l vs C: 0.78  0.14 mmol/l (p>0.05). In S group significantly (p0.05) higher levels of 1antiproteinase, allantoin, triglycerides and fibrinogen were found. High levels of free radicals together	Oxidative stress; a-tocopherol; coronary artery disease

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