Publikace detail

High Hepatic Stearoyl-CoA Desaturase-1 (SCD-1) Index is associated with low Liver Fat and high Insulin Sensitivity in obese Humans

Rok: 2006

Druh publikace: článek ve sborníku

Název zdroje: Diabetes

Název nakladatele: American Diabetes Association

Místo vydání: Alexandria

Strana od-do: A331

Tituly:

Jazyk	Název	Abstrakt	Klíčová slova
cze	Vysoký index jaterní stearoyl-CoA desaturasy?1 (SCD-1) souvisí s nízkým obsahem jaterního tuku a vysokou citlivostí k insulinu u obézních lidí	Vysoký index jaterní stearoyl-CoA desaturasy?1 (SCD-1) souvisí s nízkým obsahem jaterního tuku a vysokou citlivostí k insulinu u obézních lidí	stearoyl-CoA desaturasa, jaterní tuk, citlivost k insulinu, obezita
eng	High Hepatic Stearoyl-CoA Desaturase-1 (SCD-1) Index is associated with low Liver Fat and high Insulin Sensitivity in obese Humans	SCD-1 catalyzes the synthesis of monounsaturated fatty acids (FA) from saturated FA. It is imperative for the assembly of very low density lipoprotein (VLDL) particles, which transport FA from liver to adipose tissue and other sites. Studies in animals suggest that SCD-1 deficiency is beneficial for metabolism. However, in humans data are conflicting. We applied an elaborate method to measure an index of hepatic SCD-1 activity. First, we determined the pattern of FA in the lipid fraction of the VLDL triglycerides by ultracentrifugation followed by thin layer and gas chromatography in plasma samples from 54 healthy subjects. The oleoyl-CoA (C18:1, n9) / stearoyl-CoA (C18:0) ratio was calculated as an index of hepatic SCD-1 activity, thereafter. Insulin sensitivity (IS) was estimated from an oral glucose tolerance test (OGTT) and determined during a euglycemic clamp (n=48). Liver fat was measured by 1H magnetic resonance spectroscopy. Gender distribution, mean age and body fat were as follows: 26 m/28 f, 44?2 y, 31?1 %. The hepatic SCD-1 activity index was negatively associated with liver fat (r=-0.28, p=0.049), independently of age, gender and body fat. It was positively associated with IS(OGTT) (r=0.42, p=0.002) and more weakly with IS(clamp) (r=0.27, p=0.07). Importantly, these relationships were dependent on overall adiposity. When subjects were divided in a lean (n=27, 26 ?5 %) and in an obese (n=27, 35 ?6 %) group by the median body fat, the significant relationships were absent in the lean group (liver fat: p=0.34, IS(OGTT): p=0.75, IS(clamp): p=0.24). However, they were strengthened in the obese group (p=0.004, p=0.0002, p=0.006). After a 9 month lifestyle intervention with diet and increase in physical activity, a high SCD-1 activity index at baseline was associated with a larger increase in IS(clamp, adjusted) in the obese (p=0.04) but not in the lean (p=0.35) group. We conclude that hepatic SCD-1 may be an important regulator of liver fa	stearoyl-CoA desaturase-1; liver fat; insulin sensitivity; obesity

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