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Studying the glycosylation of Francisella tularensis lipoprotein FTH_1071 through a combination of glycoprotein enrichment techniques and mass spektrometry
Autoři: Balonová Lucie | Hernychová Lenka | Mann Benjamin F. | Bílková Zuzana | Novotný Miloš. V.
Rok: 2010
Druh publikace: ostatní - článek ve sborníku
Název zdroje: 25th International Symposium on Microscale BioSeparations MSB 2010 : Final Program & Book of Abstracts
Název nakladatele: Ústav analytické chemie AV ČR, v. v. i.
Místo vydání: Brno
Strana od-do: 102-102
Tituly:
Jazyk Název Abstrakt Klíčová slova
eng Studying the glycosylation of Francisella tularensis lipoprotein FTH_1071 through a combination of glycoprotein enrichment techniques and mass spektrometry The presence of glycosylation in bacteria has been shown to impact the function of proteins modified by glycans in terms of their implication in adhesiveness and invasion to host cells. Investigation of Francisella tularensis glycoproteome revealed the lipoprotein FTH_1071, together with other proteins, as being possibly glycosylated. In a present study, we draw attention to the protein FTH_1071 that was recently found to be essential for virulence of both F. tularensis subspecies, holarctica and tularensis Glycosylation;Francisella tularensis, lipoprotein FTH_1071, Mass spectrometry