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Publikace detail

The effect of substitution on the cytotoxicity of molybdenum(II) and tungsten(II) compounds

Autoři: Honzíček Jan | Vinklárek Jaromír | Padělková Zdeňka | Šebestová Lucie | Foltánová Karolína | Řezáčová Martina

Rok: 2012

Druh publikace: článek v odborném periodiku

Název zdroje: Journal of Organometallic Chemistry

Strana od-do: 258-268

Tituly:

Jazyk	Název	Abstrakt	Klíčová slova
cze	Vliv substitutce na cytotoxicitu sloučenin molybdenu a wolframu	Série allylových sloučenin molybdenu [(eta(3)-C3H5)Mo(CO)(2)L2Cl], [(eta(3)-C3H4COOMe)Mo(CO)(2)L2Br], cyklopentadienylových sloučenin molybdenu [(eta(5)-C5H4R)Mo(CO)(2)L-2][BF4] (R = H, 4-MeOC6H4CH2, 3,4,5-(MeO)(3)C6H2CH2), indenylových sloučenin molybdenu [(eta(5)-C9H6R)Mo(CO)(2)L-2][BF4] (R = H, 4-MeOC6H4CH2) a cyklopentadienylových sloučenin wolframu [(eta(5)-C5H5)W(CO)(2)L-2][BF4], kde L-2 je N,N''-chelatující ligand byly připraveny a charakterizovány.	molybden; wolfram; cytotoxicita
eng	The effect of substitution on the cytotoxicity of molybdenum(II) and tungsten(II) compounds	A series of allyl molybdenum [(eta(3)-C3H5)Mo(CO)(2)L2Cl], [(eta(3)-C3H4COOMe)Mo(CO)(2)L2Br], cyclopentadienyl molybdenum [(eta(5)-C5H4R)Mo(CO)(2)L-2][BF4] (R = H, 4-MeOC6H4CH2, 3,4,5-(MeO)(3)C6H2CH2), indenyl molybdenum [(eta(5)-C9H6R)Mo(CO)(2)L-2][BF4] (R = H, 4-MeOC6H4CH2) and cyclopentadienyl tungsten compounds [(eta(5)-C5H5)W(CO)(2)L-2][BF4], where L-2 is N,N''-chelating ligand, were synthesized and characterized. The in vitro assay on human leukemia cells MOLT-4 has shown that the substitution in the p-ligand has lower effect of on cytotoxicity than exchange of the N,N''-chelating ligand. Nevertheless, even this modification can lead to considerable enhance of cytotoxicity as was evidenced on the series of the indenyl molybdenum(II) compounds.	molybdenum; cyclopentadienyl; indenyl; X-ray diffraction; cytotoxicity; leukemia therapy