Publikace detail

Synthesis and characterization of pH sensitive conjugate of isoniazid - poly(ethylene glycol)-b-poly(L-lysine)

Autoři: Sedlák Miloš | Grusová Ludmila | Imramovský Aleš

Rok: 2012

Druh publikace: ostatní - přednáška nebo poster

Strana od-do: nestránkováno

Tituly:

Jazyk	Název	Abstrakt	Klíčová slova
eng	Synthesis and characterization of pH sensitive conjugate of isoniazid - poly(ethylene glycol)-b-poly(L-lysine)	The present work deals with synthesis and characterization of a new type of conjugate of INH with block copolymer poly(ethylene glycol)-b-poly(L-lysine) which is considered to be fully biocompatible, non-toxic and has been often used for drug delivery systems. The kinetics of acid-catalyzed (pH 2-7) hydrolysis of INH–PEG-b-PLL conjugate was studied under in vitro conditions by HPLC. The prepared conjugate represents promising transport systems of INH.	Synthesis; conjugate; isoniazid; polyethylene glycol-b-polyL-lysine

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