Publikace detail

Synthesis and Cytostatic activity of Pt(II) complexes of intramolecularly coordinated phosphine and stibine ligands

Rok: 2012

Druh publikace: článek v odborném periodiku

Název zdroje: Applied Organometallic Chemistry

Název nakladatele: John Wiley & Sons Ltd.

Místo vydání: Chichester

Strana od-do: 237-245

Tituly:

Jazyk	Název	Abstrakt	Klíčová slova
cze	Syntéza a cytotoxická aktivita Pt komplexů obsahujících fosfínové a stibinové ligandy.	Intramolekulárně koordinované fosfíny a stibiny L1PPh2 (1), L2PPh2 (2) a L2SbPh2 (3) byly připraveny. Tyto ligandy byly použity na přípravu platnatých komplexů trans-{[2,6-(tBuOCH2)2C6H3]PPh2}2PtCl2 (4), cis-{[2,6-(Me2NCH2)2C6H3]PPh2}PtCl2 (5), a cis-{[2,6-(Me2NCH2)2C6H3]SbPh2}PtCl2 (6).	Y, C, Y-ligandy, platina, cheláty, biologické testy, cytotoxická studie
eng	Synthesis and Cytostatic activity of Pt(II) complexes of intramolecularly coordinated phosphine and stibine ligands	The intramolecularly coordinated phosphine and stibine ligands L1PPh2 (1), L2PPh2 (2) and L2SbPh2 (3) containing Y,C,Y-chelating ligands, L1?=?2,6-(tBuOCH2)2C6H4- and L2?=?2,6-(Me2NCH2)2C6H4-, were prepared and characterized. The treatment of these ligands 13 with PtCl2 yielded complexes trans-{[2,6-(tBuOCH2)2C6H3]PPh2}2PtCl2 (4), cis-{[2,6-(Me2NCH2)2C6H3]PPh2}PtCl2 (5), and cis-{[2,6-(Me2NCH2)2C6H3]SbPh2}PtCl2 (6) as the result of different ability of the starting compounds 13 to complex platinum centre. Compounds 16 were characterized by 1H, 13C and 31P NMR spectroscopy and electrospray ionization mass spectrometry, and molecular structures of 36 were determined by X-ray diffraction analysis. The substitution reactions of complexes 46 were also studied. The reaction of 5 and 6 with NaI yielded complexes {[2,6-(Me2NCH2)2C6H3]PPh2}PtI2 (7) and {[2,6-(Me2NCH2)2C6H3]SbPh2}PtI2 (8), while the same reaction of 4 with NaI did not proceed. As the compounds 7 and 8 structurally resemble cisplatin, complex {{[2-(Me2NCH2)-6-(Me2NHCH2)C6H3]PPh2}PtCl2}+Cl- (9) was prepared as water-soluble platinum complex. The cytotoxic effect of complex 9 was evaluated.	Y; C; Y-ligands; platinum; chelates; biological tests; cytotoxic study

Vyhledávání

Přihlášení pro studenty

Přihlášení pro zaměstnance

Publikace detail

Katedry

Ústavy a pracoviště

Jak nás najdete?

Služby

Často hledáte