Publikace detail

Inverse neighboring group participation: New type of reaction mechanism

Autoři: Hanusek Jiří | Váňa Jiří | Sedlák Miloš | Kammel Richard | Roithová Jana

Rok: 2014

Druh publikace: ostatní - přednáška nebo poster

Strana od-do: nestránkováno

Tituly:

Jazyk	Název	Abstrakt	Klíčová slova
eng	Inverse neighboring group participation: New type of reaction mechanism	Recently, we have studied2 an unexpected course of rearrangement of S-(1(3H)-isobenzofuranone-3-yl)-N,N-dimethylisothiuronium bromide giving N,N’-dimethyl-N-(3-oxo-1,3-dihydro-2-benzofuran-1-yl)-thiourea. A detailed experimental and DFT study of this S to N alkyl migration provided evidence for the existence of an unusual double displacement mechanism involving two consecutive back-side SN2 reactions where a carboxylate anion has a crucial role both as a leaving group as well as an internal nucleophile.	Inverse neighboring group participation; reaction mechanism

Vyhledávání