Univerzita PardubiceFakulta chemicko- technologická

Univerzita Pardubice

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Publikace detail

Synthesis of substituted tetrahydroquinolines by the intramolecular N-arylation of enaminones

Autoři: Doušová Hana | Horák Radim | Šimůnek Petr | Padělková Zdeňka

Rok: 2014

Druh publikace: ostatní - přednáška nebo poster

Strana od-do: nestránkováno

Tituly:

Jazyk	Název	Abstrakt	Klíčová slova
eng	Synthesis of substituted tetrahydroquinolines by the intramolecular N-arylation of enaminones	We developed a simple, new method for synthesis of 2-aroylmethylidene-1,2,3,4-tetrahydroquinolines via an intramolecular transition-metal catalyzed N-arylation of enaminones containing bromine or chlorine atom. The appropriate conditions for the cyclization of the enaminones were found according to the optimization study. The prepared tetrahydroquinolines are the direct precursor of Galipea Officinalis tetrahydroquinoline alkaloids.	tetrahydroquinolines; N-arylation; enaminones