Publikace detail

Influence of Silica Shell on Toxicity of Manganese Perovskite Magnetic Nanoparticles

Autoři: Dědourková Tereza | Veverka Miroslav | Veverka Pavel | Zelenka Jiří | Svoboda Ladislav

Rok: 2014

Druh publikace: ostatní - článek ve sborníku

Název zdroje: ICNFA'14 Proceedings

Název nakladatele: International Academy of Science, Engineering, and Technology (International ASET)

Místo vydání: Ottawa

Strana od-do: "129-1"-"129-2"

Tituly:

Jazyk	Název	Abstrakt	Klíčová slova
eng	Influence of Silica Shell on Toxicity of Manganese Perovskite Magnetic Nanoparticles	Complex magnetic oxides as core materials are interesting because their magnetic properties can be regulated by various ways very well. These magnetic nanoparticles can be interesting for application in biomedicine as a contrast agent for magnetic resonance imaging or as a colloidal mediator for destruction of cancer cells by magnetic fluid hyperthermia. Magnetic nanoparticles of manganite La0.75Sr0.25MnO3 were synthesized by sol - gel method. Prepared magnetic cores had to be converted into a stable and non toxic suspension to allow their administration either by intratumoural or intravenous way. For this purpose coating by silica shell was chosen, which provides stabilization by electrostatic repulsion. Silica shell was formed by polycondensation reactions of tetraethoxysilane hydrolytic products. Thickness of silica shell can significantly influence magnetic cores toxicity and quality of the suspension.	Magnetic Nanoparticles;Sol-gel Technique;Medical Applications;Magnetic Fluid Hyperthermia;Magnetic Resonance Imaging

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