Publikace detail

Green Electrochemical Sensors Based on Boron Doped Diamond and Silver Amalgam for Sensitive Voltammetric Determination of Antineoplastic Agent Methotrexate

Autoři: Šelešovská Renáta | Bandžuchová Lenka | Chalupník Miroslav

Rok: 2014

Druh publikace: ostatní - článek ve sborníku

Název zdroje: 47th Heyrovsky discussion on electrochemistry of organic and bioactive compounds

Název nakladatele: Ústav fyzikální chemie Jaroslava Heyrovského AV ČR

Místo vydání: Praha

Strana od-do: 54

Tituly:

Jazyk	Název	Abstrakt	Klíčová slova
eng	Green Electrochemical Sensors Based on Boron Doped Diamond and Silver Amalgam for Sensitive Voltammetric Determination of Antineoplastic Agent Methotrexate	Methotrexate (MTX) is an antimetabolite and antifolate drug used in treatment of cancer and autoimmune diseases. It acts by inhibiting the metabolism of folic acid. Methotrexate was originally used as part of combination chemotherapy regimens to treat many kinds of cancers. It is still the mainstay for the treatment of many neoplastic disorders including acute lymphoblastic leukaemia. The structure of MTX is analogous to folic acid, it differs only in a methyl group connected to the amino group of amino benzoic acid (N(10)) and the amino group which is substituted on C4 on pyridine circle. The voltammetric behavior of methotrexate using unmodified boron-doped diamond electrode (BDDE) [1], mercury meniscus modified (m-AgSAE) and polished silver solid amalgam electrode (p-AgSAE) [2] is described in present paper. Optimum working conditions for differential pulse voltammetric determination of MTX were found and proposed sensitive methods were employed in the analyses of pharmaceutical preparations.	Voltammetry; Boron-doped diamond electrode; Antineoplastic agent; Methotrexate

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