Univerzita PardubiceFakulta chemicko- technologická

Univerzita Pardubice

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Publikace detail

Thiol-ene-based monolithic microreactors

Autoři: Novotný Jakub | Lafleur Josiane P. | Kutter Jörg P.

Rok: 2014

Druh publikace: ostatní - přednáška nebo poster

Strana od-do: nestránkováno

Tituly:

Jazyk	Název	Abstrakt	Klíčová slova
eng	Thiol-ene-based monolithic microreactors	Thiol-enes are UV-curable copolymers prepared from a mixture of thiol- and allyl-group containing monomers. Radical reaction between thiolic and allylic group shows characteristics of the so called "click" chemistry – a group of strong, rapid and specific synthetic reactions requiring only mild conditions. Curing is fast, often initiated without the need for addition of photoinitiator. Properties of the resulting material are influenced by the ratio of the functional groups present in the monomer mixture. Structures were micromilled in PMMA and replicated in PDMS. The resulting PDMS replicas were used as molds for the thiol-ene chips (40% excess thiol). The thiol-ene slabs (2 mm thick) were cured by exposition to collimated UV-light. A thiol-ene emulsion (40% excess ene thiol-ene) was prepared by mixing thoroughly 1 part of thiol-ene to 4 parts of methanol. The mixture was introduced inside the thiol-ene microchannel. After curing with a collimated UV-light, surface modification of the monolith via thiol-ene click chemistry is possible. The monolith mixtures, using methanol as porogen, form emulsions (or dispersions) of thiol ene droplets in a continuous phase of solvent. Stirring causes formation of micrometer-sized thiol-ene droplets. When exposed to UV-light, the droplets solidify into bead-like structures which are fused together forming a monolithic network of interconnected beads fused with the wall of the channel. Microreactors for glycoprotein deglycosylation were prepared using this method.	Thiol-ene; monolith; microreactor