Publikace detail

Improved detection of multiphosphorylated peptides using novel TiO2 based nanomaterials

Autoři: Kupčík Rudolf | Macák Jan | Řehulka Pavel | Bílková Zuzana

Rok: 2014

Druh publikace: ostatní - přednáška nebo poster

Strana od-do: nestránkováno

Tituly:

Jazyk	Název	Abstrakt	Klíčová slova
eng	Improved detection of multiphosphorylated peptides using novel TiO2 based nanomaterials	• One of the challenges in phosphoproteomics is the separation and analysis of multiply phosphorylated peptides • A widely used enrichment technique for phosphorylated peptides is technique utilizing the metal oxides, i.e. TiO2 • TiO2 is able to bind multiply phosphorylated peptides as well as monophosphorylated peptides but the efficitent elution of the them is difficult due to the extremely high binding affinity (1) • Aim of our work is to introduce the novel nanomaterial based on TiO2 which can increase the number of multiphosphorylated peptides • Second aim of our work is to separate multiphosphorylated peptides from monophosphorylated peptides	mass spectrometry, phosphoproteomics, TiO2, nanomaterials

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