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LINOLEIC ACID, DIHOMO-Γ-LINOLENIC ACID AND TOTAL CONTENT OF MUFA AND VLCSFA IN ERYTHROCYTE MEMBRANES PREDICT INCREASE OF INFLAMMATORY RESPONSE TO CORONARY STENT IMPLANTATION

Rok: 2014

Druh publikace: ostatní - přednáška nebo poster

Strana od-do: nestránkováno

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Jazyk	Název	Abstrakt	Klíčová slova
eng	LINOLEIC ACID, DIHOMO-Γ-LINOLENIC ACID AND TOTAL CONTENT OF MUFA AND VLCSFA IN ERYTHROCYTE MEMBRANES PREDICT INCREASE OF INFLAMMATORY RESPONSE TO CORONARY STENT IMPLANTATION	Percutaneous transluminal coronary angioplasty (PTCA) induces an inflammatory reaction that is crucial in the pathogenesis of neointimal proliferation, which is the main cause of stent restenosis. Many inflammatory cytokines, as mediators of inflammation, are closely associated with the fatty acid profile.We study biochemical aspects of complications associated with PTCA and the role of fatty acids in the development of inflammatory reaction. It was found significant increase of inflammatory reaction characterised by hs-CRP an SAA with maximum after 48 h post PTCA as well as oxidative stress (MDA). In case of IL-6 maximum was at 24 hours. The initial levels of total amounts of groups of fatty acids (SFA, trans-MUFA, cis-MUFA, n-3 PUFA and n-6 PUFA) and individual fatty acids of these groups in erythrocyte membranes and plasma lipid fractions (PL, DG, FFA, TG and CE) were correlated with increase of CRP, IL-6 and SAA concentration as well as individually fatty acids of these groups. In case of erythrocyte membrane there were statistically significant positive Spearman correlations between increase of IL-6 and C18:2 n-6 (r=0.59) and C20:3 (r=0.70) from group of n-6 PUFA and with very long chain saturated fatty acids (VLCSFA) (r=0.51), especially with C22:0 (r=0.56) and C24:0 (r=0.54). Negative correlation with IL-6 was found in case of MUFA – palmitoleic acid (r=-0.47) and total trans MUFA (r=-0.54). It was found negative correlation between SAA and total n-3 PUFA. Significant negative correlation between increase of MDA and values of MUFA – oleic (r=-0.45) acid, vaccenic acid (r=-0.46) and total SFA (r=-0.46). The total content of VLCSFA (especially, behenic and lignoceric), a high content of linoleic acid and dihomo-γ-linolenic acid (but not the overall proportion of n-6 PUFA) and a reduced content of MUFA in erythrocyte membranes significantly predict increase of inflammatory response after PTCA.	percutaneous transluminal coronary angioplasty; inflammatory reaction; fatty acid profile

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