Publikace detail

Comparison of inhibitory effects between acetaminophen-glutathione conjugate and reduced glutathione in human glutathione reductase

Rok: 2014

Druh publikace: článek v odborném periodiku

Název zdroje: Journal of Applied Toxicology

Název nakladatele: Wiley-Blackwell

Strana od-do: 968-973

Tituly:

Jazyk	Název	Abstrakt	Klíčová slova
cze	Srovnání inhibice mezi konjugátem acetaminofenu a glutathionu u lidské glutathionreduktasy	Acetaminofenové poškození je častou příčinou jaterního selhání, a proto jsme se zaměřili na srovnání inhibice mezi konjugátem acetaminofenu a glutathionu u lidské glutathionreduktasy.	acetaminofenová toxicita; glutathion; glutathionreduktasa.
eng	Comparison of inhibitory effects between acetaminophen-glutathione conjugate and reduced glutathione in human glutathione reductase	Acetaminophen overdose is the most frequent cause of acute liver injury. The main mechanism of acetaminophen toxicity has been attributed to oxidation of acetaminophen. The type of enzyme inhibition was observed to be competitive in the cases of both APAP-SG and glutathione. As glutathione inhibits GR activity in cells under physiological conditions, the rate of enzyme inhibition ought to be weaker in the case of glutathione depletion that is typical of acetaminophen overdose. Notably, however, enzyme activity likely remains inhibited due to the presence of APAP-SG, which might enhance the pro-oxidative status in the cell.	acetaminophen toxicity; glutathione; glutathione reductase

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