Publikace detail

Estimation of toxic effect of acetaminophen metabolite in isolated mitochondria

Rok: 2014

Druh publikace: ostatní - článek ve sborníku

Název zdroje: Toxicology Letters

Název nakladatele: Elsevier Ireland Ltd

Místo vydání: Shannon

Strana od-do: s76

Tituly:

Jazyk	Název	Abstrakt	Klíčová slova
eng	Estimation of toxic effect of acetaminophen metabolite in isolated mitochondria	Acetaminophen (APAP) is frequently used analgetic and antipyretic drug. It is a safe drug at therapeutic doses but the overdose causes hepatotoxicity. The exact cause of cell damage remains unknown. The most important detoxification pathway acting in overdose is oxidation of APAP by cytochrome P450 to a substance, which is detoxified by reaction with glutathione. This APAP-SG conjugate has been considered as detoxification product generally. However, based on the literature and our previous results, we postulated that the conjugate could possess a toxic effect.	Acetaminophen; mitochondria; toxicity; glutathione; ROS

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