Publikace detail

Acetaminophen toxicity – estimation of a new possible mechanism of cell impairment

Autoři: Roušar Tomáš | Vrbová Martina | Roušarová Erika | Červinková Zuzana | Česla Petr

Rok: 2014

Druh publikace: ostatní - přednáška nebo poster

Název zdroje: Toxicology Letters

Název nakladatele: Elsevier Ireland Ltd

Místo vydání: Shannon

Strana od-do: nestránkováno

Tituly:

Jazyk	Název	Abstrakt	Klíčová slova
eng	Acetaminophen toxicity – estimation of a new possible mechanism of cell impairment	Acetaminophen is a safe drug at therapeutic doses. However, after overdose, it can cause cell impairment that may lead even to acute liver or kidney failure. Although the toxic mechanism has been studied for 40 years, some principles of toxicity remain unknown. In addition, a number of clinical studies focused on occurrence of acetaminophen toxicity at therapeutic doses have been published and some rather unexplainable reports from animal studies have appeared as well. Therefore, it is obvious that some parts contributing acetaminophen toxicity likely remain to be found.	Acetaminophen toxicity; glutathione; ROS

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