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DETERMINATION OF DISTRIBUTION CONSTANTS OF ANTIOXIDANTS BETWEEN LIPOSOMES, ALKYLSULFATE MICELLES, OCTANOL AND WATER USING ELECTROKINETIC CHROMATOGRAPHY

Autoři: Váňová Jana | Liimatta Laura J. | Česla Petr | Wiedmer Susanne K.

Rok: 2016

Druh publikace: ostatní - přednáška nebo poster

Strana od-do: nestránkováno

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Jazyk	Název	Abstrakt	Klíčová slova
eng	DETERMINATION OF DISTRIBUTION CONSTANTS OF ANTIOXIDANTS BETWEEN LIPOSOMES, ALKYLSULFATE MICELLES, OCTANOL AND WATER USING ELECTROKINETIC CHROMATOGRAPHY	The in vivo effects of the antioxidants are dependent on their lipophilicity, which govern membrane and protein interactions. Two electrokinetic systems, i.e. micellar electrokinetic chromatography (MEKC) and liposome electrokinetic chromatography (LEKC), were used for studying of the lipophilicity of antioxidants. Micelles of sodium decyl sulfate (SDeS) and sodium dodecyl sulfate (SDS) were used as the pseudostationary phase in MEKC and the liposomes were composed of mixtures of 1-palmitoyl-2-oleyl-sn-glycerophosphatidylcholine (POPC) and 1-palmitoyl-2-oleoyl-sn-phosphatidylserine (POPS) or 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidyl-DL-glycerol (POPG) in LEKC. The retention factors of the studied analytes were determined at pH 7.4. The micelle and liposome/aqueous distribution constants for studied antioxidants were experimentally determined and compared with values of octanol/aqueous distribution constants.

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