Publikace detail

Amidophosphine-stabilized palladium complexes catalyse Suzuki-Miyaura cross-couplings in aqueous media

Rok: 2016

Druh publikace: článek v odborném periodiku

Název zdroje: Applied Organometallic Chemistry

Název nakladatele: John Wiley & Sons Ltd.

Místo vydání: Chichester

Strana od-do: 1036-1042

Tituly:

Jazyk	Název	Abstrakt	Klíčová slova
cze	Pd komplexy jako katalyzátory ve vodném prostředí	Byla zjištěna efektivní procedura pro Suzuki-Miyaura reackci ve vodném prostředí. Pro tento účel byly připraveny Pd komplexy trans-{(LPPh2)-P-3}(2)PdCl2 (3), trans-{L(3)PPhtBu}(2)PdCl2 (4), [Pd(eta(3)-C3H5)((LPPh2)-P-3)Cl] (5) a {Pd[2-(Me2NCH2)C6H4]((LPPh2)-P-3)Cl} (6).	Pd komplexy; Suzuki-Miyaura; katalyzátory; vodné prostředí
eng	Amidophosphine-stabilized palladium complexes catalyse Suzuki-Miyaura cross-couplings in aqueous media	We report a simple and efficient procedure for Suzuki-Miyaura reactions in aqueous media catalysed by amidophosphine-stabilized palladium complexes trans-{(LPPh2)-P-3}(2)PdCl2 (3), trans-{L(3)PPhtBu}(2)PdCl2 (4), [Pd(eta(3)-C3H5)((LPPh2)-P-3)Cl] (5) and {Pd[2-(Me2NCH2)C6H4]((LPPh2)-P-3)Cl} (6). The acidity of the NH proton in complexes 3-6 plays an important role in their catalytic activity. In addition, the palladium complexes cis-{(LPPh2)-P-1}PdCl2 (1) and trans-{(LPPh2)-P-2}(2)PdCl2 (2) stabilized by phosphines containing Y, C, Y-chelating ligands L-1,L-2 have also been found to be useful catalysts for Suzuki-Miyaura reactions in aqueous media. The method can be effectively applied to both activated and deactivated aryl bromides yielding high or moderate conversions. The catalytic activity of couplings performed in pure water increases when utilizing a Pd complex with more acidic NH protons. A decrease of palladium concentration from 1.0 to 0.5 mol% does not lead to a substantial loss of conversion. In addition, Pd complex 1 can be efficiently recovered using two-phase system extraction.	aqueous media; palladium; Suzuki-Miyaura; C C coupling

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