Publikace detail

Release kinetics of tramadol hydrochloride from solid drug formulations

Autoři: Myslíková Kateřina | Komersová Alena | Lochař Václav

Rok: 2016

Druh publikace: článek v odborném periodiku

Název zdroje: Scientific Papers of the University of Pardubice, Series A, Faculty of Chemical Technology

Strana od-do: 67-79

Tituly:

Jazyk	Název	Abstrakt	Klíčová slova
cze	Rozpouštěcí kinetika tramadol hydrochloridu z pevných lékových forem	Cílem práce je prezentovat použití reakční disoluční kinetiky pro vývoj disolučního profilu léčiv. Jako modelová substance byl vybrán tramadol hydrochlorid.	rozpouštěcí kinetika; tramadol hydrochlorid; pevná léčiva; formulace
eng	Release kinetics of tramadol hydrochloride from solid drug formulations	The aim of this paper is to present the use of a reaction and a dissolution kinetic approach for evaluating the dissolution profile of a drug. As model substances, two controlled-release formulations (with different type of matrix) with tramadol hydrochloride were chosen. Release kinetics of tramadol hydrochloride was studied at isothermal conditions (37 °C) and at different pH values for media used for dissolution. The dissolution profiles obtained by using HPLC with UV detection were fitted by the first-order kinetic model, Korsmeyer–Peppas, Higuchi, and Weibull models. The main results of regression analysis were the determination of the first-order release rate constant (k1), the release exponent (n) from Korsmeyer–Peppas model, Higuchi constant (KH), and the parameters of Weibull model.	Release kinetics; tramadol hydrochloride; solid drug; formulations

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