Publikace detail

EXTENDED RELEASE OF PENTOXIFYLLINE - DUAL MATRIX TABLETS CONTAINING POLYVINYL ALCOHOL AND GLYCERYL DIBEHENATE

Autoři: Komersová Alena | Lochař Václav | Slezáková Barbora | Mužíková J

Rok: 2018

Druh publikace: ostatní - článek ve sborníku

Název zdroje: Book of abstracts of the 6th International Conference on Chemical Technology

Název nakladatele: Česká společnost průmyslové chemie

Místo vydání: Praha

Strana od-do: L7-L7

Tituly:

Jazyk	Název	Abstrakt	Klíčová slova
eng	EXTENDED RELEASE OF PENTOXIFYLLINE - DUAL MATRIX TABLETS CONTAINING POLYVINYL ALCOHOL AND GLYCERYL DIBEHENATE	The aim of this in vitro study was to evaluate the possibility of using of dual matrix tablets containing polyvinyl alcohol and glyceryl dibehenate for extended release of pentoxifylline. The studied matrix tablets were prepared by the direct compression method, Prosolv® SMCC 90 was used as a coprocessed dry binder and magnesium stearate as a lubricant. The effect of tablets composition on the rate of pentoxifylline release was evaluated by the non-linear regression analysis of the dissolution profiles. In accordance with requirements of FDA, also alcohol-induced dose dumping was also studied.	dual matrix tablet; pentoxifylline; release; dissolution POLYVINYL; ALCOHOL; AND; GLYCERYL; DIBEHENATE

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