Publikace detail

RELEASE KINETICS OF TRAMADOL HYDROCHLORIDE FROM MATRICES CONTAINING MIXTURE OF BIOPOLYMERS – ALGINATE AND CHITOSANE

Autoři: Matzick Kevin | Slezáková Barbora | Komersová Alena | Lochař Václav

Rok: 2019

Druh publikace: ostatní - článek ve sborníku

Název zdroje: 7th International Conference on Chemical Technology : book of abstracts

Název nakladatele: Česká společnost průmyslové chemie

Místo vydání: Praha

Strana od-do: PH7-PH7

Tituly:

Jazyk	Název	Abstrakt	Klíčová slova
eng	RELEASE KINETICS OF TRAMADOL HYDROCHLORIDE FROM MATRICES CONTAINING MIXTURE OF BIOPOLYMERS – ALGINATE AND CHITOSANE	Aim of this study is to select appropriate formulations of matrix tablets containing biopolymers, based on dissolution tests. Studied tablets consisted chitosane, sodium alginate (or their combination), well soluble model drug – tramadol hydrochloride, dry binder – Prosolv® SMCC 90 and lubricant – magnesium stearate. All tablets were prepared by direct compression method with a hand press. As a dissolution medium were used acidic medium simulating gastric fluid (pH 1,2) and phosphate buffer simulating intestinal fluid (pH=6,8). An integral part of the experiment was visual detection of the drug release from matrix by swelling event. erosion of the tablet in dependence of the composition of matrix and pH of the solution.	release kinetics; tramadol; alginate; chitosane

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