Publikace detail

Development of carbon nanotube based sensor for determination of antiarrhythmic drug propafenone in pharmaceutical and biological samples

Autoři: Nawar Amir Shaaban Farag Moham | Bakirhan N. B. | Švancara Ivan | Ozkan S. A.

Rok: 2019

Druh publikace: ostatní - přednáška nebo poster

Strana od-do: nestránkováno

Tituly:

Jazyk	Název	Abstrakt	Klíčová slova
eng	Development of carbon nanotube based sensor for determination of antiarrhythmic drug propafenone in pharmaceutical and biological samples	A novel electroanalytical method for the determination of propafenone (PPF) in pharmaceutical dosage form and biological fluids using the glassy carbon electrode modified with NH2-functionalized multi-walled carbon nanotubes as a sensitive sensor. Several working conditions necessary for PPF electrochemical determination using differential pulse voltammetry, such as pH, scan rate, accumulation time and potential were optimized. The results showed a significant enhancement of the peak current after modification of the electrode. The calibration curves of PPF showed a linearity from 0.1 to 10 μM, characterized by limits of quantification 0.03 μM and limit of detection 0.01 μM. The results of model analysis by the proposed method were satisfactory and statistically evaluated.

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