Publikace detail

Wound healing of different molecular weight of hyaluronan; in-vivo study

Rok: 2016

Druh publikace: článek v odborném periodiku

Název zdroje: International Journal of Biological Macromolecules

Název nakladatele: Elsevier Science BV

Místo vydání: Amsterdam

Strana od-do: 582-591

Tituly:

Jazyk	Název	Abstrakt	Klíčová slova
cze	Wound healing of different molecular weight of hyaluronan; in-vivo study	Paper deals with wound healing of different molecular weight of hyaluronan; in-vivo study.
eng	Wound healing of different molecular weight of hyaluronan; in-vivo study	Recruitment of cells and mediators is altered during impaired wound healing, thereby delaying this process. To overcome this problem, the correlation of wound healing in older rats, and the impact of different molecular weight of hyaluronan without silver nanoparticles; (low-HA1), (High-HA2), (Medium-HA3) and with silver nanoparticles (High-HA4) is investigated. The superior HA were selected to be further investigated onto diabetic wounds. Our results pointed to a marked deficiency in wounds granulation in older rats, which was accompanied with impairment of healing process. In older rats group treated with HA2 or HA4, granulation and dermal construction were improved. Furthermore, the number of pathogenic bacteria on wounds was declined throughout the first 24 h by HA2 and HA4. The wound size in HA4-treated older rats was significantly smaller than that in other HA1, HA2 or HA3-treated older ones. Also, diabetes impaired the level of inflammatory cytokine, in diabetic model. On contrary, HA4 was found to normalize the level of inflammatory cytokine, in the diabetic model. Furthermore, HA4 was found to recover all oxidative and toxicity markers in diabetic models. This data confirms the critical role of HA4 to improve granulation and inflammatory mediators in impaired older and diabetic rat wound healing.	Wound healing; Hyaluronan; Animal models

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