Mgr. Šárka Štěpánková, Ph.D.

Vzdělání a akademická kvalifikace

Přehled zaměstnání

Publikace

SACHLEVICIUTE, U. - GONZALEZ, G. - KVASNICOVA, M. - ŠTĚPÁNKOVÁ, Š. - KLEIZIENE, N. - BIELIAUSKAS, A. - ZATLOUKAL, M. - STRNAD, M. - SLOK, F. - KVASNICA, M. - SACKUS, A. - ZUKAUSKAITE, A. Synthesis and neuroprotective activity of 3-aryl-3-azetidinyl acetic acid methyl ester derivatives Archiv der Pharmazie, 2023, vol. 356, no. 12, s. 2300378. ISSN: 0365-6233.

GONZALEZ, G. - KVASNICA, M. - SVRČKOVÁ, K. - ŠTĚPÁNKOVÁ, Š. - SANTOS, J. - PERINA, M. - JORDA, R. - LOPES, S. - MELO, T. Ring-fused 3 beta-acetoxyandrost-5-enes as novel neuroprotective agents with cholinesterase inhibitory properties Journal of Steroid Biochemistry and Molecular Biology, 2023, vol. 225, no. January, s. 106194. ISSN: 0960-0760.

HOUNGBEDJI, N. - ŠTĚPÁNKOVÁ, Š. - PFLEGR, V. - SVRČKOVÁ, K. - SVARCOVA, M. - VINSOVA, J. - KRATKY, M. Novel Inhibitors of Acetyl- and Butyrylcholinesterase Derived from Benzohydrazides: Synthesis, Evaluation and Docking Study Pharmaceuticals, 2023, vol. 16, no. 2, s. 172. ISSN: 1424-8247.

PFLEGR, V. - ŠTĚPÁNKOVÁ, Š. - SVRČKOVÁ, K. - SVARCOVA, M. - VINSOVA, J. - KRATKY, M. 5-Aryl-1,3,4-oxadiazol-2-amines Decorated with Long Alkyl and Their Analogues: Synthesis, Acetyl- and Butyrylcholinesterase Inhibition and Docking Study Pharmaceuticals, 2022, vol. 15, no. 4, s. 400. ISSN: 1424-8247.

KRATKY, M. - SVRČKOVÁ, K. - VU, Q. - ŠTĚPÁNKOVÁ, Š. - VINSOVA, J. Hydrazones of 4-(Trifluoromethyl)benzohydrazide as New Inhibitors of Acetyl- and Butyrylcholinesterase Molecules, 2021, vol. 26, no. 4, s. 989. ISSN: 1420-3049.

KOS, J. - STRHARSKY, T. - ŠTĚPÁNKOVÁ, Š. - SVRČKOVÁ, K. - ORAVEC, M. - HOSEK, J. - IMRAMOVSKÝ, A. - JAMPILEK, J. Trimethoxycinnamates and Their Cholinesterase Inhibitory Activity Applied Science - Basel, 2021, vol. 11, no. 10, s. 4691. ISSN: 2076-3417.

KIELCZEWSKA, U. - JORDA, R. - GONZALEZ, G. - MORZYCKI, J. - AJANI, H. - SVRČKOVÁ, K. - ŠTĚPÁNKOVÁ, Š. - WOJTKIELEWICZ, A. The synthesis and cholinesterase inhibitory activities of solasodine analogues with seven-membered F ring Journal of Steroid Biochemistry and Molecular Biology, 2021, vol. 205, no. January, s. 105776. ISSN: 0960-0760.

KRÁTKÝ, M. - ŠTĚPÁNKOVÁ, Š. - KONEČNÁ, K. - SVRČKOVÁ, K. - MAIXNEROVÁ, J. - ŠVARCOVÁ, M. - JANĎOUREK, O. - TREJTNAR, F. - VINŠOVÁ, J. Novel Aminoguanidine Hydrazone Analogues: From Potential Antimicrobial Agents to Potent Cholinesterase Inhibitors Pharmaceuticals, 2021, vol. 14, no. 12, s. 1229. ISSN: 1424-8247.

KRATKY, M. - VU, Q. - ŠTĚPÁNKOVÁ, Š. - MARUCA, A. - SILVA, T. - AMBROZ, M. - PFLEGR, V. - ROCCA, R. - SVRČKOVÁ, K. - ALCARO, S. - BORGES, F. - VINSOVA, J. Novel propargylamine-based inhibitors of cholinesterases and monoamine oxidases: Synthesis, biological evaluation and docking study Bioorganic Chemistry, 2021, vol. 116, no. November, s. 105301. ISSN: 0045-2068.

KOS, J. - KOZIK, V. - PINDJAKOVA, D. - JANKECH, T. - SMOLINSKI, A. - ŠTĚPÁNKOVÁ, Š. - HOSEK, J. - ORAVEC, M. - JAMPILEK, J. - BAK, A. Synthesis and Hybrid SAR Property Modeling of Novel Cholinesterase Inhibitors International Journal of Molecular Sciences, 2021, vol. 22, no. April, s. 3444. ISSN: 1661-6596.

MAGAR, P. - PARRAVICINI, O. - ŠTĚPÁNKOVÁ, Š. - SVRČKOVÁ, K. - GARRO, A. - JENDRZEJEWSKA, I. - PAUK, K. - HOSEK, J. - JAMPILEK, J. - ENRIZ, R. - IMRAMOVSKÝ, A. Novel Sulfonamide-Based Carbamates as Selective Inhibitors of BChE International Journal of Molecular Sciences, 2021, vol. 22, no. 17, s. 9447. ISSN: 1661-6596.

ŠTĚPÁNKOVÁ, Š. - VOTOČKOVÁ, K. - SVRČKOVÁ, K. USE OF INDOXYL ACETATE AS A SUBSTRATE FOR ACETYLCHOLINESTERASE. In ChemZi. Bratislava: Slovenská chemická spoločnosť pri SAV, 2021. s. 175-175 s.

KRATKY, M. - ŠTĚPÁNKOVÁ, Š. - BRABLIKOVA, M. - SVRČKOVÁ, K. - SVARCOVA, M. - VINSOVA, J. Novel Iodinated Hydrazide-hydrazones and their Analogues as Acetyl- and Butyrylcholinesterase Inhibitors Current Topics in Medicinal Chemistry, 2020, vol. 20, no. 23, s. 2106-2117. ISSN: 1568-0266.

KRATKY, M. - BARANYAI, Z. - ŠTĚPÁNKOVÁ, Š. - SVRČKOVÁ, K. - SVARCOVA, M. - STOLARIKOVA, J. - HORVATH, L. - BOSZE, S. - VINSOVA, J. N-Alkyl-2-[4-(trifluoromethyl)benzoyl]hydrazine-1-carboxamides and Their Analogues: Synthesis and Multitarget Biological Activity Molecules, 2020, vol. 25, no. 10, s. 2268. ISSN: 1420-3049.

KRATKY, M. - JAKLOVA, K. - ŠTĚPÁNKOVÁ, Š. - SVRČKOVÁ, K. - PFLEGR, V. - VINSOVA, J. N-[3,5-Bis(trifluoromethyl)phenyl]-5-bromo-2-hydroxybenzamide Analogues: Novel Acetyl- and Butyrylcholinesterase inhibitors Current Topics in Medicinal Chemistry, 2020, vol. 20, no. 23, s. 2094-2105. ISSN: 1568-0266.

BAK, A. - KOZIK, V. - KOZAKIEWICZ, D. - GAJCY, K. - STRUB, D. - SWIETLICKA, A. - ŠTĚPÁNKOVÁ, Š. - IMRAMOVSKÝ, A. - POLANSKI, J. - SMOLINSKI, A. - JAMPILEK, J. Novel Benzene-Based Carbamates for AChE/BChE Inhibition: Synthesis and Ligand/Structure-Oriented SAR Study International Journal of Molecular Sciences, 2019, vol. 20, no. 7, s. "1524-1"-"1524-25". ISSN: 1422-0067.

KRATKY, M. - ŠTĚPÁNKOVÁ, Š. - HOUNGBEDJI, N. - VOSATKA, R. - SVRČKOVÁ, K. - VINSOVA, J. 2-Hydroxy-N-phenylbenzamides and Their Esters Inhibit Acetylcholinesterase and Butyrylcholinesterase Biomolecules, 2019, vol. 9, no. 11, s. "698-1"-"698-16". ISSN: 2218-273X.

CHLEBEK, J. - KORABECNY, J. - DOLEZAL, R. - ŠTĚPÁNKOVÁ, Š. - PEREZ, D. - HOSTALKOVA, A. - OPLETAL, L. - CAHLIKOVA, L. - MACAKOVA, K. - KUCERA, T. - HRABINOVA, M. - JUN, D. In Vitro and In Silico Acetylcholinesterase Inhibitory Activity of Thalictricavine and Canadine and Their Predicted Penetration across the Blood-Brain Barrier Molecules, 2019, vol. 24, no. 7, s. "1340-1"-"1340-11". ISSN: 1420-3049.

VORČÁKOVÁ, K. - MAJEKOVA, M. - HORÁKOVÁ, E. - DRABINA, P. - SEDLÁK, M. - ŠTĚPÁNKOVÁ, Š. Synthesis and characterization of new inhibitors of cholinesterases based on N-phenylcarbamates: In vitro study of inhibitory effect, type of inhibition, lipophilicity and molecular docking Bioorganic Chemistry, 2018, vol. 78, no. August, s. 280-289. ISSN: 0045-2068.

KRATKY, M. - ŠTĚPÁNKOVÁ, Š. - VORČÁKOVÁ, K. - VINSOVA, J. Investigation of salicylanilide and 4-chlorophenol-based N-monosubstituted carbamates as potential inhibitors of acetyl- and butyrylcholinesterase Bioorganic Chemistry, 2018, vol. 80, no. October, s. 668-673. ISSN: 0045-2068.

PIZOVÁ, H. - HAVELKOVÁ, M. - BOBAL, P. - ŠTĚPÁNKOVÁ, Š. - KAUEROVÁ, T. - BAK, A. - KOLLAR, P. - KOZIK, V. - ORAVEC, M. - IMRAMOVSKÝ, A. - JAMPÍLEK, J. Proline-Based Carbamates as Cholinesterase Inhibitors Molecules, 2017, vol. 22, no. 11, s. "1969-1"-"1969-25". ISSN: 1420-3049.

HORÁKOVÁ, E. - DRABINA, P. - BRŮČKOVÁ, L. - VORČÁKOVÁ, K. - ŠTĚPÁNKOVÁ, Š. - SEDLÁK, M. Synthesis and in vitro evaluation of novel N-cycloalkylcarbamates as potential cholinesterase inhibitors Monatshefte fur Chemie, 2017, vol. 148, no. 12, s. 2143–2153. ISSN: 0026-9247.

KRATKY, M. - ŠTĚPÁNKOVÁ, Š. - VORČÁKOVÁ, K. - NAVRATILOVA, L. - TREJTNAR, F. - STOLARIKOVA, J. - VINSOVA, J. Synthesis of Readily Available Fluorophenylalanine Derivatives and Investigation of Their Biological Activity Bioorganic Chemistry, 2017, vol. 71, no. April, s. 244-256. ISSN: 0045-2068.

PEJCHAL, V. - ŠTĚPÁNKOVÁ, Š. - PEJCHALOVÁ, M. - KRÁLOVEC, K. - HAVELEK, R. - RŮŽIČKOVÁ, Z. - AJANI, H. - LO, R. - LEPSIK, M. Synthesis, structural characterization, docking, lipophilicity and cytotoxicity of 1-[(1R)-1-(6-fluoro-1,3-benzothiazol-2-yl)ethyl]-3-alkyl carbamates, novel acetylcholinesterase and butyrylcholinesterase pseudo-irreversible inhibitors Bioorganic & Medicinal Chemistry, 2016, vol. 24, no. 7, s. 1560-1572. ISSN: 0968-0896.

HORÁKOVÁ, E. - DRABINA, P. - BROŽ, B. - ŠTĚPÁNKOVÁ, Š. - VORČÁKOVÁ, K. - KRÁLOVEC, K. - HAVELEK, R. - SEDLÁK, M. Synthesis, characterization and in vitro evaluation of substituted N-(2-phenylcyclopropyl)carbamates as acetyl- and butyrylcholinesterase inhibitors Journal of enzyme inhibition and medicinal chemistry, 2016, vol. 31, no. Supp. 3, s. 173-179. ISSN: 1475-6366.

VANĚČKOVÁ, N. - HOŠŤÁLKOVÁ, A. - ŠAFRATOVÁ, M. - KUNEŠ, J. - HULCOVÁ, D. - HRABINOVÁ, M. - DOSKOČIL, I. - ŠTĚPÁNKOVÁ, Š. - OPLETAL, L. - NOVÁKOVÁ, L. - JUN, D. - CHLEBEK, J. - CAHLÍKOVÁ, L. Isolation of Amaryllidaceae alkaloids from Nerine bowdenii W. Watson and their biological activities RSC Advances, 2016, vol. 6, no. 83, s. 80114–80120. ISSN: 2046-2069.

KRÁTKÝ, M. - ŠTĚPÁNKOVÁ, Š. - VORČÁKOVÁ, K. - VINŠOVÁ, J. Synthesis and in vitro evaluation of novel rhodanine derivatives as potential cholinesterase inhibitors Bioorganic Chemistry, 2016, vol. 68, no. October, s. 23-29. ISSN: 0045-2068.

KRÁTKÝ, M. - ŠTĚPÁNKOVÁ, Š. - VORČÁKOVÁ, K. - ŠVARCOVÁ, M. - VINŠOVÁ, J. Novel Cholinesterases Inhibitors Based on O-Aromatic N,N-Disubstituted Carbamates and Thiocarbamates Molecules, 2016, vol. 21, no. 2, s. "191-1"-"191-10". ISSN: 1420-3049.

ŠTĚPÁNKOVÁ, Š. - VORČÁKOVÁ, K. Cholinesterase based biosensors Journal of enzyme inhibition and medicinal chemistry, 2016, vol. 31, no. Suppl. 3, s. 180-193. ISSN: 1475-6366.

VORČÁKOVÁ, K. - ŠTĚPÁNKOVÁ, Š. - SEDLÁK, M. - VYTŘAS, K. Electrochemical Sensors for the Estimation of the Inhibitory Effect of Phenylcarbamates to Cholinesterase Chemosensors, 2015, vol. 3, no. 4, s. 274-283. ISSN: 2227-9040.

KRATKÝ, M. - ŠTĚPÁNKOVÁ, Š. - VORČÁKOVÁ, K. - VINŠOVÁ, J. Salicylanilide diethyl phosphates as cholinesterases inhibitors Bioorganic Chemistry, 2015, vol. 58, no. February, s. 48-52. ISSN: 0045-2068.

CAHLIKOVA, L. - PEREZ, D. - ŠTĚPÁNKOVÁ, Š. - CHLEBEK, J. - SAFRATOVA, M. - HOST'ALKOVA, A. - OPLETAL, L. In Vitro Inhibitory Effects of 8-O-Demethylmaritidine and Undulatine on Acetylcholinesterase and Their Predicted Penetration across the Blood-Brain Barrier Journal of Natural Products, 2015, vol. 78, no. 6, s. 1189-1192. ISSN: 0163-3864.

VORČÁKOVÁ, K. - ŠTĚPÁNKOVÁ, Š. - IMRAMOVSKÝ, A. Benzothiazoles as effective inhibitors of cholinesterases: Kinetics and mechanism of inhibition Scientific Papers of the University of Pardubice, Series A, Faculty of Chemical Technology, 2015, vol. 21, no. září, s. 31-43. ISSN: 1211-5541.

VORČÁKOVÁ, K. - ŠTĚPÁNKOVÁ, Š. - KRÁTKY, M. - VINŠOVÁ, J. Application of Human Cholinesterase in Determination of Inhibitory Effect of Salicylanilide diethyl phosphates. In 4th International Miniconference of PhD Students: When Biochemistry Meets Pharmacology and Toxicology. Bratislava: Ústav experimentálnej farmakológie a toxikológie SAV, 2015. s. 17-20 s. ISBN 978-80-971042-5-2.

VINSOVA, J. - KRATKY, M. - KOMLOOVA, M. - DADAPEER, E. - ŠTĚPÁNKOVÁ, Š. - VORČÁKOVÁ, K. - STOLARIKOVA, J. Diethyl 2-(Phenylcarbamoyl)phenyl Phosphorothioates: Synthesis, Antimycobacterial Activity and Cholinesterase Inhibition Molecules, 2014, vol. 19, no. 6, s. 7152-7168. ISSN: 1420-3049.

HAVLASOVÁ, J. - SAFRATOVA, M. - SIATKA, T. - ŠTĚPÁNKOVÁ, Š. - NOVAK, Z. - LOCAREK, M. - OPLETAL, L. - HRABINOVA, M. - JUN, D. - BENESOVA, N. - KUNES, J. - CAHLIKOVA, L. Chemical Composition of Bioactive Alkaloid Extracts from Some Narcissus Species and Varieties and their Biological Activity Natural Product Communications, 2014, vol. 9, no. 8, s. 1151-1155. ISSN: 1934-578X.

KOVÁŘOVÁ, M. - KOMERS, K. - ŠTĚPÁNKOVÁ, Š. - PAŘÍK, P. - ČEGAN, A. New Method for the Determination of the Half Inhibition Concentration (IC50) of Cholinesterase Inhibitors Zeitschrift fuer Naturforschung C-A Journal of Biosciences, 2013, vol. 68, no. 3-4, s. 133-138. ISSN: 0939-5075.

ŠTĚPÁNKOVÁ, Š. - VORČÁKOVÁ, K. Inhibitory effect of carbamates in two types of cholinesterases Scientific Papers of the University of Pardubice, Series A, Faculty of Chemical Technology, 2013, vol. 19, no. prosinec, s. 49-56. ISSN: 1211-5541.

IMRAMOVSKÝ, A. - PEJCHAL, V. - ŠTĚPÁNKOVÁ, Š. - VORČÁKOVÁ, K. - JAMPÍLEK, J. - VANČO, J. - ŠIMŮNEK, P. - KRÁLOVEC, K. - BRŮČKOVÁ, L. - MANDÍKOVÁ, J. - TREJTNAR, F. Synthesis and in vitro evaluation of new derivatives of 2-substituted-6-fluorobenzo[d]thiazoles as cholinesterase inhibitors Bioorganic & Medicinal Chemistry, 2013, vol. 21, no. 7, s. 1735-1748. ISSN: 0968-0896.

IMRAMOVSKÝ, A. - ŠTĚPÁNKOVÁ, Š. - VANČO, J. - PAUK, K. - MONREAL-FERRIZ, J. - VINŠOVÁ, J. - JAMPILEK, J. Acetylcholinesterase-Inhibiting Activity of Salicylanilide N-Alkylcarbamates and Their Molecular Docking Molecules, 2012, vol. 17, no. 9, s. 10142-10158. ISSN: 1420-3049.

VORČÁKOVÁ, K. - ŠTĚPÁNKOVÁ, Š. - IMRAMOVSKÝ, A. Stanovenie anticholinesterasovej aktivity vybraných benzothiazolov. In Študentská vedecká konferencia PriF UK 2012. Bratislava: Univerzita Komenského v Bratislave, 2012. s. 1063-1067 s. ISBN 978-80-223-3213-2.

VORČÁKOVÁ, K. - ŠTĚPÁNKOVÁ, Š. - ZORIČ, P. - SEDLÁK, M. - METELKA, R. - VYTŘAS, K. Application of Electrochemical Sensors for Determination of Anticholinesterase Activity and Immobilization of Enzyme. In Sensing in Electroanalysis Vol. 7. Pardubice: Univerzita Pardubice, 2012. s. 409-422 s. ISBN 978-80-7395-563-2.

PEJCHAL, V. - ŠTĚPÁNKOVÁ, Š. - DRABINA, P. Synthesis of 1-[(1R)-1-(6-Fluoro-1,3-benzothiazol-2-yl)ethyl]-3-substituted Phenyl Ureas and Their Inhibition Activity to Acetylcholinesterase and Butyrylcholinesterase Journal of Heterocyclic Chemistry, 2011, vol. 48, no. 1, s. 57-62. ISSN: 0022-152X.

PEJCHAL, V. - ŠTĚPÁNKOVÁ, Š. - PADĚLKOVÁ, Z. - IMRAMOVSKÝ, A. - JAMPÍLEK, J. Substituted Imidazolidine-2,4,5-triones: Synthesis and Inhibition of Cholinergic Enzymes. Molecules, 2011, vol. 16, no. 9, s. 7565-7582. ISSN: 1420-3049.

KOVÁŘOVÁ, M. - KOMERS, K. - ŠTĚPÁNKOVÁ, Š. - ČEGAN, A. Inhibition of acetylcholinesterase by 14 achiral and five chiral imidazole derivates Bioresource Technology, 2010, vol. 101, no. 15, s. 6281-6283. ISSN: 0960-8524.

SEDLÁK, M. - HANUSEK, J. - DRABINA, P. - ŠTĚPÁNKOVÁ, Š. - ČEGAN, A. Substituted benzyl N-phenylcarbamates - their solvolysis and inhibition activity to acetylcholinesterase and butyrylcholinesterase ARKIVOC, 2009, vol. -, no. 7, s. 1-11. ISSN: 1424-6376.

ŠTĚPÁNKOVÁ, Š. - PAŘÍK, P. - KOVÁŘOVÁ, M. - KOMERS, K. Stanovení indexu pI50 nových inhibitorů cholinesteráz. In ChemZi. Bratislava: Slovenská chemická spoločnosť pri SAV, 2009. s. 125-125 s.

ŠTĚPÁNKOVÁ, Š. - KOMERS, K. Cholinesterases and Cholinesterase Inhibitors Current Enzyme Inhibition, 2008, vol. 4, no. 4, s. 160-171. ISSN: 1573-4080.

SOUKUPOVÁ, L. - KOMERSOVÁ, A. - KOMERS, K. - ŠTĚPÁNKOVÁ, Š. - ČEGAN, A. Kinetic of the Total Hydrolysis of Acetyl-β-methylcholine by Acetylcholinesterase Reaction Kinetics and Catalysis Letters, 2008, vol. 95, no. 2, s. 205-211. ISSN: 0133-1736.

ŠTĚPÁNKOVÁ, Š. - KOMERS, K. - KOMERSOVÁ, A. - MASOPUSTOVÁ, M. - ČEGAN, A. Inhibition of Cholinesterases by Dialkylcarbamates Zeitschrift fuer Naturforschung C-A Journal of Biosciences, 2007, vol. 62c, no. N, s. 308-310. ISSN: 0939-5075.

KOMERSOVÁ, A. - MASOPUSTOVÁ, M. - KOMERS, K. - ŠTĚPÁNKOVÁ, Š. - ČEGAN, A. In vitro Inhibition of Cholinesterases by Carbamates ? A Kinetic Study Zeitschrift fuer Naturforschung C-A Journal of Biosciences, 2007, vol. 62c, no. N, s. 305-307. ISSN: 0939-5075.

ŠTĚPÁNKOVÁ, Š. - KOMERS, K. - KOMERSOVÁ, A. - ČEGAN, A. Stanovení kinetických konstant neinhibovaných a inhibovaných hydrolýz acetylcholinu. In ChemZi. Bratislava: Slovenská chemická spoločnosť pri SAV, 2007. s. 79-80 s.

ZDRAŽILOVÁ, P. - ŠTĚPÁNKOVÁ, Š. - KOMERSOVÁ, A. - VRÁNOVÁ, M. - KOMERS, K. - ČEGAN, A. Kinetics of 13 new cholinesterase inhibitors Zeitschrift fuer Naturforschung C-A Journal of Biosciences, 2006, vol. 61c, no. 7-8, s. 611-617. ISSN: 0939-5075.

ZDRAŽILOVÁ, P. - ŠTĚPÁNKOVÁ, Š. - VRÁNOVÁ, M. - KOMERS, K. - KOMERSOVÁ, A. - ČEGAN, A. Kinetics of total enzymatic hydrolysis of acetylcholine and acetylthiocholine Zeitschrift fuer Naturforschung C-A Journal of Biosciences, 2006, vol. 61c, no. 3-4, s. 289-294. ISSN: 0939-5075.

ZDRAŽILOVÁ, P. - KOMERS, K. - ŠTĚPÁNKOVÁ, Š. - KOMERSOVÁ, A. Kinetics of Hydrolysis of Acetylthiocholine by Cholinesterases.. In European Congress of Young Chemists, Youngchem 2004. Varšava: Warsaw University of Technology, 2004. s. 111 s. ISBN N.

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