Publikace detail

The diminishing of oxidative stress by diet optimization may reduce the occurrence of metabolic syndrome in obese persons.

Rok: 2007

Druh publikace: článek ve sborníku

Název zdroje: Clinical Chemistry and Laboratory Medicine Special Supplement

Název nakladatele: Walter de Gruyter GmbH & Co. KG

Místo vydání: Berlin

Strana od-do: S152

Tituly:

Jazyk	Název	Abstrakt	Klíčová slova
cze	Snížení oxidačního stresu optimalizací diety může snižovat výskyt metabolického syndromu u obézních osob	Snížení oxidačního stresu optimalizací diety může snižovat výskyt metabolického syndromu u obézních osob	metabolický syndrom; oxidační stres; snížení energetického příjmu
eng	The diminishing of oxidative stress by diet optimization may reduce the occurrence of metabolic syndrome in obese persons.	Background. Metabolic syndrome (MS), associated with high cardiovascular morbidity and mortality, has increasing impact. The aim of our study was to evaluate the influence of diet optimization on oxidative stress and MS occurrence in obese patients. Methods. Oxidative stress markers (total amount of free radicals, malondialdehyde, allantoin, a-1antiproteinase, GSSG/GSH ratio), total antioxidant capacity and lipid standardised a-tocopherol were determined in obese patients with restricted energy intake with lowering dietary carbohydrates (A; n=15) and those with the same grade of obesity but not following dietary recommendations (B; n=17) and in 48 healthy controls. In patients we evaluated presence of MS according to NCEP ATPIII. Free radical concentration was determined by direct method based on chlorophyllin acceptance of electrons, total antioxidant capacity using kit TAS (Randox, UK), malondialdehyde and a-tocopherol by HPLC. Plasma levels of glucose, triglycerides, HDL-ch, LDL-ch, fibrinogen, uric acid, BMI and waistline were followed. Results. Group A exhibited lower oxidative stress markers - free radicals (A: 5.18+-1.68 mmol/l vs B: 8.43+-3.66 mmol/l, p<0.01), GSSG/GSH ratio (A: 11.74+-5.01 % vs B: 15.38+-5.93 %, p<0.05) and higher antioxidants: lipid standardised a-tocopherol (A: 3.70+-0.51 umol/l vs B: 3.35+-0.60, p<0.05) and ceruloplasmin. Conclusion. Energy intake restriction by 2 000 kJ, mainly due to carbohydrate limitations, decreased oxidative stress and simultaneously increased lipid-standardised a-tocopherol and ceruloplasmin in obese people. These changes correlated with diminished MS occurrence by about 50 %, even when weight loss did not occur.	metabolic syndrome; oxidative stress; energy intake restriction

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