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Model of non-alcoholic fatty liver disease in rats for toxicological studies.
Autoři: Kučera Otto | Křiváková Pavla | Roušar Tomáš | Garnol Tomáš | Bolehovská Radka | Hroch Martin | Mazurová Yvetta | Lotková Halka | Červinková Zuzana
Rok: 2009
Druh publikace: ostatní - článek ve sborníku
Název zdroje: Acta Medica (Hradec Králové)
Název nakladatele: Univerzita Karlova v Praze
Místo vydání: Praha
Strana od-do: 42-42
Tituly:
Jazyk Název Abstrakt Klíčová slova
cze Model of non-alcoholic fatty liver disease in rats for toxicological studies. Non-alcoholic fatty liver disease (NAFLD) is a common condition associated with metabolic syndrome and represents a wide spectrum of liver affections ranging from benign hepatic steatosis, to non-alcoholic steatohepatitis (NASH) that may progress to cirrhosis and even to end-stage liver disease. The aim of this project was to introduce and describe a suitable nutritional model of NAFLD on rats for comparison of toxic effects of model hepatotoxins on intact liver and liver affected by NAFLD. There were no significant differences among groups in serum biochemical parameters except for lower concentration of TAG in MFGD and especially in HFGD against ST-1 after 3 and 6 weeks. There was a significant increase in expression of UCP-2 and tissue IL-6 (but not TGFbeta1) in groups fed by diets with higher fat content in comparison with ST-1.
eng Model of non-alcoholic fatty liver disease in rats for toxicological studies. Non-alcoholic fatty liver disease (NAFLD) is a common condition associated with metabolic syndrome and represents a wide spectrum of liver affections ranging from benign hepatic steatosis, to non-alcoholic steatohepatitis (NASH) that may progress to cirrhosis and even to end-stage liver disease. The aim of this project was to introduce and describe a suitable nutritional model of NAFLD on rats for comparison of toxic effects of model hepatotoxins on intact liver and liver affected by NAFLD. There were no significant differences among groups in serum biochemical parameters except for lower concentration of TAG in MFGD and especially in HFGD against ST-1 after 3 and 6 weeks. There was a significant increase in expression of UCP-2 and tissue IL-6 (but not TGFbeta1) in groups fed by diets with higher fat content in comparison with ST-1. NAFLD; liver; steatosis; NASH.

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