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Miminizing the Effects of Multicollinearity in the Polynomial Regression of Age Relationships and Sex Differences in Serum Levels of Pregnelonone Sulfate in Healthy Subjects
Autoři: Meloun Milan | Hill Martin | Včeláková Helena
Rok: 2009
Druh publikace: článek v odborném periodiku
Název zdroje: Clinical Chemistry and Laboratory Medicine
Název nakladatele: Walter de Gruyter GmbH & Co. KG
Místo vydání: Berlin
Strana od-do: 464-470
Tituly:
Jazyk Název Abstrakt Klíčová slova
cze
eng Miminizing the Effects of Multicollinearity in the Polynomial Regression of Age Relationships and Sex Differences in Serum Levels of Pregnelonone Sulfate in Healthy Subjects Pregnenolone-sulfate (PregS) is known as a steroid conjugate positively modulating N-methyl-D-aspartate (NMDA) receptors on neuronal membranes. These receptors are responsible for permeability of calcium channels and activation of neuronal function. Neuroactivating effect of PregS is also exerted via noncompetitive negative modulation of GABAA receptors regulating the chloride influx. Recently, a penetrability of blood-brain barrier for PregS was found in rat, but some experiments being in agreement with this finding were reported even beforehand. Multicollinearity; Principal component regression; Steroids; Age Relationship of Pregnenolone Sulfate