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Miminizing the Effects of Multicollinearity in the Polynomial Regression of Age Relationships and Sex Differences in Serum Levels of Pregnelonone Sulfate in Healthy Subjects

Autoři: Meloun Milan | Hill Martin | Včeláková Helena

Rok: 2009

Druh publikace: článek v odborném periodiku

Název zdroje: Clinical Chemistry and Laboratory Medicine

Název nakladatele: Walter de Gruyter GmbH & Co. KG

Místo vydání: Berlin

Strana od-do: 464-470

Tituly:

Jazyk	Název	Abstrakt	Klíčová slova
cze
eng	Miminizing the Effects of Multicollinearity in the Polynomial Regression of Age Relationships and Sex Differences in Serum Levels of Pregnelonone Sulfate in Healthy Subjects	Pregnenolone-sulfate (PregS) is known as a steroid conjugate positively modulating N-methyl-D-aspartate (NMDA) receptors on neuronal membranes. These receptors are responsible for permeability of calcium channels and activation of neuronal function. Neuroactivating effect of PregS is also exerted via noncompetitive negative modulation of GABAA receptors regulating the chloride influx. Recently, a penetrability of blood-brain barrier for PregS was found in rat, but some experiments being in agreement with this finding were reported even beforehand.	Multicollinearity; Principal component regression; Steroids; Age Relationship of Pregnenolone Sulfate

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