Publikace detail

Design and efficient synthesis of amino acid derived 2-substituted imidazoles by palladium-catalyzed cross-coupling reactions

Autoři: Bureš Filip | Marek Aleš | Kulhánek Jiří

Rok: 2009

Druh publikace: ostatní - přednáška nebo poster

Název zdroje: 42nd IUPAC Congress

Název nakladatele: Royal Society of Chemistry

Místo vydání: Cambridge

Strana od-do: nestránkováno

Tituly:

Jazyk	Název	Abstrakt	Klíčová slova
cze	Design and efficient synthesis of amino acid derived 2-substituted imidazoles by palladium-catalyzed cross-coupling reactions	Optically active imidazole derivatives substituted at the 2-position can be prepared in moderate to good yields by Negishi as well as Suzuki-Miyaura cross-couplings as the key synthetic steps. The reaction sequence involves N-protection, whereby both generated regioisomers could by separated by CC, and selective 2-lithiation. Subsequent transmetalation to zinc or an iodine quench affords reactants for Pd-catalyzed cross-couplings with (hetero)aromatics.	imidazole, Suzuki-Miyaura reaction, Negishi reaction
eng	Design and efficient synthesis of amino acid derived 2-substituted imidazoles by palladium-catalyzed cross-coupling reactions	Optically active imidazole derivatives substituted at the 2-position can be prepared in moderate to good yields by Negishi as well as Suzuki-Miyaura cross-couplings as the key synthetic steps. The reaction sequence involves N-protection, whereby both generated regioisomers could by separated by CC, and selective 2-lithiation. Subsequent transmetalation to zinc or an iodine quench affords reactants for Pd-catalyzed cross-couplings with (hetero)aromatics.	imidazole, Suzuki-Miyaura reaction, Negishi reaction

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