Publikace detail

New chiral synthons of 13C- or 15N-labeled α-aminoacids.

Rok: 2007

Druh publikace: článek v odborném periodiku

Název zdroje: Journal of Labelled Compounds and Radiopharmaceuticals

Název nakladatele: John Wiley & Sons Ltd.

Místo vydání: Chichester

Strana od-do: 554-555

Tituly:

Jazyk	Název	Abstrakt	Klíčová slova
cze	New chiral synthons of 13C- or 15N-labeled α-aminoacids.	For the synthesis of a structure carrying a label in any of the above-mentioned positions, the corresponding labelled glycine synthon could be prepared from commercially available mono-, di- or tri-labelled glycine. This synthon is further monoalkylated with a suitable electrophile in order to introduce a (protected) side chain, followed by methylation by labelled or non-labelled methyl iodide. An optimization was done in order to increase yields of the complexes and decrease consumption of expensive labelled glycine. Similar optimization of synthesis of a precursor for a-(13C)methyltyrosine gave the ratio of BPB:amino acid:nickel nitrate ¼ 1:1.4:1.5. This ratio allows to achieve 87% yield of the complex. The development of more diastereoselective synthons is underway.
eng	New chiral synthons of 13C- or 15N-labeled α-aminoacids.	For the synthesis of a structure carrying a label in any of the above-mentioned positions, the corresponding labelled glycine synthon could be prepared from commercially available mono-, di- or tri-labelled glycine. This synthon is further monoalkylated with a suitable electrophile in order to introduce a (protected) side chain, followed by methylation by labelled or non-labelled methyl iodide. An optimization was done in order to increase yields of the complexes and decrease consumption of expensive labelled glycine. Similar optimization of synthesis of a precursor for a-(13C)methyltyrosine gave the ratio of BPB:amino acid:nickel nitrate ¼ 1:1.4:1.5. This ratio allows to achieve 87% yield of the complex. The development of more diastereoselective synthons is underway.	amino acids; asymetris synthesis; carbon- 13; nitrogen- 15; labelling

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